Myh10 myosin, heavy polypeptide 10, non-muscle [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myh10provided by MGI
Official Full Name: myosin, heavy polypeptide 10, non-muscleprovided by MGI
Primary source: MGI:MGI:1930780
See related: Ensembl:ENSMUSG00000020900 AllianceGenome:MGI:1930780
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fltn; NM2B; Myhn2; SMemb; Myhn-2; NMHC-B; NMMHC-B; NMHCII-B; NMHC II-B; NMMHC-IIB; mKIAA3005; NMMHC II-b; 5730504C04Rik; 9330167F11Rik
Summary: Predicted to enable several functions, including RNA binding activity; actin filament binding activity; and adenyl ribonucleotide binding activity. Involved in postsynaptic actin cytoskeleton organization. Acts upstream of or within several processes, including animal organ development; generation of neurons; and plasma membrane repair. Located in several cellular components, including brush border; cytoskeleton; and growth cone. Part of myosin II complex. Is active in glutamatergic synapse. Is expressed in several structures, including early embryo; eye; heart and pericardium; neural ectoderm; and respiratory system. Orthologous to human MYH10 (myosin heavy chain 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 43.2), CNS E14 (RPKM 26.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 41.95 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (68581228..68707451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (68691915..68816626)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity.
Title: Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity.
Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
Title: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
MYH10 Governs Adipocyte Function and Adipogenesis through Its Interaction with GLUT4.
Title: MYH10 Governs Adipocyte Function and Adipogenesis through Its Interaction with GLUT4.
Filopodia powered by class x myosin promote fusion of mammalian myoblasts.
Title: Filopodia powered by class x myosin promote fusion of mammalian myoblasts.
Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease.
Title: Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease.
MYH10 plays an essential and non-redundant role in cytokinesis during meiotic cell divisions of the male germline.
Title: Non-muscle myosin IIB is essential for cytokinesis during male meiotic cell divisions.
contact guidance is preserved following loss of NM2B and that expression of NM2A alone is sufficient to establish an appropriate orientation of the cells.
Title: The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance.
knockdown of NMIIA or NMIIB lowers the growth rate and tumor volume of 3-methylcholanthrene-induced tumor in vivo.
Title: Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.
These findings reveal critical roles for Myh10 in alveologenesis at least in part via the regulation of extracellular matrix remodeling.
Title: Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.
data therefore reveal a role for NMIIA and NMIIB as negative regulators of proliferation in the mammary epithelium.
Title: Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93338 (e-PCR)
- UniSTS:91600

RH126327 (e-PCR)
- UniSTS:163035

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle distribution	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament-based movement	ISO Inferred from Sequence Orthology more info
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar Purkinje cell layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fourth ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasma membrane repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within substrate-dependent cell migration, cell extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within third ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actomyosin	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin II complex	ISO Inferred from Sequence Orthology more info
located_in myosin II filament	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IMP Inferred from Mutant Phenotype more info	PubMed
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-10

Names: cellular myosin heavy chain, type B; flectin; myosin IIB; myosin heavy chain 10, non-muscle; myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscular, type B; non-muscle myosin heavy chain B; non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain II-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175260.2 → NP_780469.1 myosin-10

See identical proteins and their annotated locations for NP_780469.1

Status: VALIDATED

Source sequence(s)

AK029236, AK147567, CJ100063

Consensus CDS

CCDS24869.1

UniProtKB/Swiss-Prot

Q5SV63, Q61879

UniProtKB/TrEMBL

Q3UH59

Related

ENSMUSP00000099671.4, ENSMUST00000102611.10

Conserved Domains (3) summary

cd14920
Location:99 → 771

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

68581228..68707451

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157089.1 → XP_036012982.1 myosin-10 isoform X1

UniProtKB/TrEMBL

Q3UH59, Q5SV64

Conserved Domains (3) summary

cd14920
Location:99 → 802

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:879 → 1959

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_036157090.1 → XP_036012983.1 myosin-10 isoform X4

UniProtKB/Swiss-Prot

Q5SV63, Q61879

UniProtKB/TrEMBL

Q3UH59

Conserved Domains (3) summary

cd14920
Location:99 → 771

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_006534489.4 → XP_006534552.1 myosin-10 isoform X1

UniProtKB/TrEMBL

Q3UH59, Q5SV64

Related

ENSMUSP00000018887.9, ENSMUST00000018887.15

Conserved Domains (3) summary

cd14920
Location:99 → 802

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:879 → 1959

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_017314835.3 → XP_017170324.1 myosin-10 isoform X3

UniProtKB/TrEMBL

Q3UH59

Conserved Domains (3) summary

cd14920
Location:99 → 781

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:858 → 1938

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_017314834.3 → XP_017170323.1 myosin-10 isoform X2

UniProtKB/TrEMBL

Q3UH59

Conserved Domains (3) summary

cd14920
Location:99 → 792

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:869 → 1949

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain