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    Rpl22l1 ribosomal protein L22 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 68028, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rpl22l1provided by MGI
    Official Full Name
    ribosomal protein L22 like 1provided by MGI
    Primary source
    MGI:MGI:1915278
    See related
    Ensembl:ENSMUSG00000039221 AllianceGenome:MGI:1915278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110001N18Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in cytosol. Orthologous to human RPL22L1 (ribosomal protein L22 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 86.2), placenta adult (RPKM 77.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl22l1 in Genome Data Viewer
    Location:
    3 A3; 3 12.27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (28859660..28861573)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (28805508..28807424)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700112D23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:28679958-28680067 Neighboring gene predicted pseudogene 6505 Neighboring gene eukaryotic translation initiation factor 5A2 Neighboring gene STARR-positive B cell enhancer ABC_E6046 Neighboring gene predicted gene, 32950 Neighboring gene predicted gene, 33051 Neighboring gene STARR-seq mESC enhancer starr_07266 Neighboring gene STARR-seq mESC enhancer starr_07267 Neighboring gene STARR-seq mESC enhancer starr_07268 Neighboring gene STARR-seq mESC enhancer starr_07269 Neighboring gene STARR-seq mESC enhancer starr_07271 Neighboring gene predicted gene, 33102 Neighboring gene predicted gene 1527

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ribosomal L22-like1 (RPL22L1) Promotes Ovarian Cancer Metastasis by Inducing Epithelial-to-Mesenchymal Transition. Wu N, et al. PLoS One, 2015. PMID 26618703, Free PMC Article
    2. The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. O'Leary MN, et al. PLoS Genet, 2013. PMID 23990801, Free PMC Article
    3. RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance. Rao S, et al. PLoS One, 2019. PMID 31581233, Free PMC Article
    4. Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis. Fahl SP, et al. J Immunol, 2022 Feb 15. PMID 35046107, Free PMC Article
    5. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Zhang Y, et al. Cell Rep, 2017 Jan 10. PMID 28076796, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis.
      Title: Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis.
    2. RPL22L1 might be a prognostic marker in colorectal cancer and predict 5-Fluorouracil responsiveness.
      Title: RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance.
    3. Rpl22, and its highly homologous paralog Rpl22-Like1 (Rpl22l1 or Like1) play critical, extraribosomal roles in embryogenesis.
      Title: Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.
    4. RPL22L1 induces epithelial-to-mesenchymal transition and is critical in maintaining the aggressive phenotype of ovarian cancer.
      Title: Ribosomal L22-like1 (RPL22L1) Promotes Ovarian Cancer Metastasis by Inducing Epithelial-to-Mesenchymal Transition.
    5. either ribosomal protein can support translation, knockdown of Rpl22l1 impairs growth of cells lacking Rpl22. Mechanistically, Rpl22 regulates Rpl22l1 directly by binding to an internal hairpin structure and repressing its expression
      Title: The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein eL22-like 1
    Names
    60S ribosomal protein L22-like 1
    large ribosomal subunit protein eL22-like 1
    NP_001334155.1
    NP_080793.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347226.3 → NP_001334155.1  ribosomal protein eL22-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122490
      Consensus CDS
      CCDS84615.1
      UniProtKB/Swiss-Prot
      Q9D7S7
      Related
      ENSMUSP00000141510.2, ENSMUST00000194649.2
      Conserved Domains (1) summary
      pfam01776
      Location:15 → 112
      Ribosomal_L22e; Ribosomal L22e protein family

    2. NM_026517.4 → NP_080793.1  ribosomal protein eL22-like 1 isoform 1

      See identical proteins and their annotated locations for NP_080793.1

      Status: VALIDATED

      Source sequence(s)
      AC122490
      Consensus CDS
      CCDS17278.1
      UniProtKB/Swiss-Prot
      Q9CXU8, Q9D7S7
      UniProtKB/TrEMBL
      Q0VBA4
      Related
      ENSMUSP00000043111.6, ENSMUST00000043867.11
      Conserved Domains (1) summary
      pfam01776
      Location:16 → 113
      Ribosomal_L22e; Ribosomal L22e protein family

    RNA

    1. NR_154888.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122490
      Related
      ENSMUST00000193168.2

    2. NR_154889.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122490

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      28859660..28861573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7S7.1 GenPept UniProtKB/Swiss-Prot:Q9D7S7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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