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    Slco1a5 solute carrier organic anion transporter family, member 1a5 [ Mus musculus (house mouse) ]

    Gene ID: 108096, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Slco1a5provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 1a5provided by MGI
    Primary source
    MGI:MGI:1351865
    See related
    Ensembl:ENSMUSG00000063975 AllianceGenome:MGI:1351865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oatp3; Oatp-3; Slc21a7
    Summary
    Predicted to enable bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport; intestinal absorption; and sodium-independent organic anion transport. Predicted to act upstream of or within ion transport. Predicted to be located in brush border membrane. Predicted to be integral component of plasma membrane. Is expressed in ear; nervous system; and thyroid gland. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 1.3), liver adult (RPKM 0.4) and 9 other tissues See more
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    Genomic context

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    See Slco1a5 in Genome Data Viewer
    Location:
    6 G2; 6 73.69 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142179953..142268707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142234227..142322981, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a8 Neighboring gene STARR-seq mESC enhancer starr_17699 Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene STARR-seq mESC enhancer starr_17700 Neighboring gene predicted gene, 18159 Neighboring gene STARR-seq mESC enhancer starr_17701 Neighboring gene predicted gene, 53313 Neighboring gene STARR-seq mESC enhancer starr_17703 Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene islet amyloid polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E6502 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1716 Neighboring gene RecQ protein-like Neighboring gene golgi transport 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine. Sugiura T, et al. Drug Metab Pharmacokinet, 2010. PMID 21084765
    2. The superfamily of organic anion transporting polypeptides. Hagenbuch B, et al. Biochim Biophys Acta, 2003 Jan 10. PMID 12507753
    3. Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Walters HC, et al. Am J Physiol Gastrointest Liver Physiol, 2000 Dec. PMID 11093941
    4. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. van de Steeg E, et al. J Clin Invest, 2010 Aug. PMID 20644253, Free PMC Article
    5. Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. Di Cosmo C, et al. J Clin Invest, 2010 Sep. PMID 20679730, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables monocarboxylic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyroid hormone transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intestinal absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocarboxylic acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 1A5
    Names
    organic anion-transporting polypeptide 3
    sodium-independent organic anion transporter 3
    solute carrier family 21 (organic anion transporter), member 7
    solute carrier family 21 member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267707.1 → NP_001254636.1  solute carrier organic anion transporter family member 1A5

      See identical proteins and their annotated locations for NP_001254636.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC102125, FQ790388
      Consensus CDS
      CCDS57464.1
      UniProtKB/Swiss-Prot
      Q91XS2, Q91YY5
      UniProtKB/TrEMBL
      A0A0G2JDD1
      Related
      ENSMUSP00000137607.2, ENSMUST00000111825.10
      Conserved Domains (3) summary
      cd06174
      Location:23 → 397
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:436 → 488
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    2. NM_130861.3 → NP_570931.1  solute carrier organic anion transporter family member 1A5

      See identical proteins and their annotated locations for NP_570931.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029706
      Consensus CDS
      CCDS57464.1
      UniProtKB/Swiss-Prot
      Q91XS2, Q91YY5
      UniProtKB/TrEMBL
      A0A0G2JDD1
      Related
      ENSMUSP00000080116.4, ENSMUST00000081380.10
      Conserved Domains (3) summary
      cd06174
      Location:23 → 397
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:436 → 488
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142179953..142268707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YY5.1 GenPept UniProtKB/Swiss-Prot:Q91YY5

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