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    Fbxo21 F-box protein 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360818, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Fbxo21provided by RGD
    Official Full Name
    F-box protein 21provided by RGD
    Primary source
    RGD:1307346
    See related
    Ensembl:ENSRNOG00000001129 AllianceGenome:RGD:1307346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Orthologous to human FBXO21 (F-box protein 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 214.8), Brain (RPKM 206.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (44231918..44266035, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38570878..38605133, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44244633..44279044, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene uncharacterized LOC134481299 Neighboring gene tescalcin Neighboring gene uncharacterized LOC120095990 Neighboring gene uncharacterized LOC120095991 Neighboring gene nitric oxide synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108338.3 → NP_001101808.2  F-box only protein 21

      Status: VALIDATED

      Source sequence(s)
      BC158866, CB582551, CB615901, CB715798, JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1M6
      Conserved Domains (2) summary
      TIGR02097
      Location:493 → 590
      yccV; hemimethylated DNA binding domain
      pfam13369
      Location:260 → 388
      Transglut_core2; Transglutaminase-like superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      44231918..44266035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089601.2 → XP_038945529.1  F-box only protein 21 isoform X1

      UniProtKB/TrEMBL
      A6J1M6, F1M5Q6
      Related
      ENSRNOP00000059243.4
      Conserved Domains (2) summary
      TIGR02097
      Location:500 → 597
      yccV; hemimethylated DNA binding domain
      pfam13369
      Location:260 → 388
      Transglut_core2; Transglutaminase-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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