Vrk3 VRK serine/threonine kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vrk3provided by RGD
Official Full Name: VRK serine/threonine kinase 3provided by RGD
Primary source: RGD:1549692
See related: Ensembl:ENSRNOG00000026517 AllianceGenome:RGD:1549692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein phosphatase binding activity and protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade and positive regulation of phosphoprotein phosphatase activity. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 139.3), Spleen (RPKM 120.8) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104379903..104407278)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95243344..95270780)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100755622..100783008)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect regulation of ERK activity by VRK3-mediated vaccinia H1-related (VHR) phosphatase activity
Title: VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

BI286500 (e-PCR)
- UniSTS:245342

BI280713 (e-PCR)
- UniSTS:249047

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: inactive serine/threonine-protein kinase VRK3

Names: serine/threonine-protein kinase VRK3; vaccinia related kinase 3

NP_001005561.2

EC 2.7.11.1

XP_063122703.1

EC 2.7.11.1

XP_063122707.1

EC 2.7.11.1

XP_063122713.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005561.2 → NP_001005561.2 inactive serine/threonine-protein kinase VRK3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F7F2H0, Q66HC2

Related

ENSRNOP00000037790.4, ENSRNOT00000035748.4

Conserved Domains (4) summary

COG0515
Location:229 → 458

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

pfam12773
Location:14 → 38

DZR; Double zinc ribbon

pfam13240
Location:13 → 35

zinc_ribbon_2; zinc-ribbon domain

cl21453
Location:143 → 445

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104379903..104407278

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266643.1 → XP_063122713.1 inactive serine/threonine-protein kinase VRK3 isoform X2
XM_063266637.1 → XP_063122707.1 inactive serine/threonine-protein kinase VRK3 isoform X1

UniProtKB/TrEMBL

F7F2H0
XM_063266633.1 → XP_063122703.1 inactive serine/threonine-protein kinase VRK3 isoform X1

UniProtKB/TrEMBL

F7F2H0