Per1 period circadian regulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Per1provided by RGD
Official Full Name: period circadian regulator 1provided by RGD
Primary source: RGD:727863
See related: Ensembl:ENSRNOG00000007387 AllianceGenome:RGD:727863
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rper1
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. [provided by RefSeq, Jan 2014]
Expression: Biased expression in Adrenal (RPKM 88.9), Heart (RPKM 58.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54299002..54313804)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53800126..53814963)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55681761..55696557)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-kappaB pathway: an in vitro and in vivo study.
Title: Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-κB pathway: an in vitro and in vivo study.
Pers reverse angiotensin II -induced vascular smooth muscle cell proliferation by targeting cyclin E expression via inhibition of the MAPK signaling pathway.
Title: Pers reverse angiotensin II -induced vascular smooth muscle cell proliferation by targeting cyclin E expression via inhibition of the MAPK signaling pathway.
rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression.
Title: rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression.
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.
Title: The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.
Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.
Title: Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.
This study demonstrated that optimal auditory conditioned fear extinction learning is reliant on the presence of normal per1 gene expression in the vmPFC as well as the presence of both circadian and training-associated elevations of glucocorticoid hormone
Title: Coordination between Prefrontal Cortex Clock Gene Expression and Corticosterone Contributes to Enhanced Conditioned Fear Extinction Recall.
Restraint stress increased Per1 mRNA in the hypothalamic paraventricular nucleus and prefrontal cortex of both sexes.
Title: Adrenal-dependent and -independent stress-induced Per1 mRNA in hypothalamic paraventricular nucleus and prefrontal cortex of male and female rats.
Sequential and tandem ChIP analyses showed that, after forced swim (FS) stress , MRs and GRs bind concomitantly to the same GRE sites within Fkbp5 and Per1 but not Sgk1 Thus, after stress, MRs and GRs seem to bind to GREs as homo- and/or heterodimers in a gene-dependent manner. MR binding to GREs at baseline seems to be restricted, whereas after stress, GR binding may facilitate cobinding of MR
Title: Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus.
Report altered expression pattern of clock genes, Per1, Per2 and Bmal1, in sub-oscillators of the rat brain and in the liver in rat model of depression.
Title: Altered Expression Pattern of Clock Genes in a Rat Model of Depression.
Study demonstrates that transcriptional activation of Per1 and Per2 via E-box enhancer sequences is necessary for the temporally specific phase shifts induced by melatonin at circadian time 10. These findings support a link between melatonin-induced signal transduction pathways activating necessary Per1 and Per2 transcription and clock resetting in the suprachiasmatic nucleus by melatonin at dusk.
Title: Melatonin Signal Transduction Pathways Require E-Box-Mediated Transcription of Per1 and Per2 to Reset the SCN Clock at Dusk.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Per1 (e-PCR), detects polymorphism
- UniSTS:527485

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IEA Inferred from Electronic Annotation more info
involved_in entrainment of circadian clock by photoperiod	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glucocorticoid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glucocorticoid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucocorticoid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hair cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of hair cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of hair cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: period circadian protein homolog 1

Names: circadian clock protein PERIOD 1; period 1; period circadian clock 1; period homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034125.1 → NP_001029297.1 period circadian protein homolog 1

See identical proteins and their annotated locations for NP_001029297.1

Status: PROVISIONAL

Source sequence(s)

AY903229

UniProtKB/Swiss-Prot

Q2KMM8, Q8CHI5

UniProtKB/TrEMBL

A0A8I6AM54, A6HFN8

Related

ENSRNOP00000053964.4, ENSRNOT00000057136.4

Conserved Domains (4) summary

cd00130
Location:360 → 461

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1079 → 1220

Period_C; Period protein 2/3C-terminal region

pfam15761
Location:6 → 59

IMUP; Immortalization up-regulated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54299002..54313804

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246613.5 → XP_006246675.1 period circadian protein homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006246675.1

UniProtKB/Swiss-Prot

Q2KMM8, Q8CHI5

UniProtKB/TrEMBL

A0A8I6AM54, A6HFN8

Conserved Domains (4) summary

cd00130
Location:360 → 461

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1079 → 1220

Period_C; Period protein 2/3C-terminal region

pfam15761
Location:6 → 59

IMUP; Immortalization up-regulated protein
XM_006246614.5 → XP_006246676.1 period circadian protein homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006246676.1

UniProtKB/Swiss-Prot

Q2KMM8, Q8CHI5

UniProtKB/TrEMBL

A0A8I6AM54, A6HFN8

Conserved Domains (4) summary

cd00130
Location:360 → 461

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1079 → 1220

Period_C; Period protein 2/3C-terminal region

pfam15761
Location:6 → 59

IMUP; Immortalization up-regulated protein