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    Rsf1 remodeling and spacing factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308839, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rsf1provided by RGD
    Official Full Name
    remodeling and spacing factor 1provided by RGD
    Primary source
    RGD:1311245
    See related
    Ensembl:ENSRNOG00000024194 AllianceGenome:RGD:1311245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hbxap
    Summary
    Predicted to enable histone binding activity and transcription coregulator activity. Predicted to be involved in several processes, including chromatin assembly; positive regulation of viral transcription; and regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be part of RSF complex. Orthologous to human RSF1 (remodeling and spacing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 93.3), Brain (RPKM 91.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rsf1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (161303596..161426326)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151892055..152015089)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162549222..162671962)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 4 Neighboring gene adipogenesis associated, Mth938 domain containing Neighboring gene ribosomal protein L35, pseudogene 4 Neighboring gene chloride nucleotide-sensitive channel 1A Neighboring gene aquaporin 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HBXAP, a novel PHD-finger protein, possesses transcription repression activity. Shamay M, et al. Genomics, 2002 Apr. PMID 11944984
    2. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. Shamay M, et al. J Biol Chem, 2002 Mar 22. PMID 11788598
    3. Functional analysis of the subunits of the chromatin assembly factor RSF. Loyola A, et al. Mol Cell Biol, 2003 Oct. PMID 12972596, Free PMC Article
    4. Requirement of RSF and FACT for transcription of chromatin templates in vitro. LeRoy G, et al. Science, 1998 Dec 4. PMID 9836642
    5. Reconstitution of recombinant chromatin establishes a requirement for histone-tail modifications during chromatin assembly and transcription. Loyola A, et al. Genes Dev, 2001 Nov 1. PMID 11691835, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone octamer slider activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RSF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    remodeling and spacing factor 1
    Names
    hepatitis B virus x associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427468.1 → NP_001414397.1  remodeling and spacing factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZGQ8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      161303596..161426326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262798.1 → XP_063118868.1  remodeling and spacing factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKD6

    2. XM_063262799.1 → XP_063118869.1  remodeling and spacing factor 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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