Slc38a2 solute carrier family 38, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc38a2provided by RGD
Official Full Name: solute carrier family 38, member 2provided by RGD
Primary source: RGD:69420
See related: Ensembl:ENSRNOG00000006305 AllianceGenome:RGD:69420
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ata2; Sat2; Atrc2; Snat2
Summary: Enables L-glutamine transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in several processes, including cellular response to mechanical stimulus; glycine betaine transport; and neutral amino acid transport. Located in several cellular components, including brush border; neuronal cell body; and sarcolemma. Biomarker of visual epilepsy. Orthologous to human SLC38A2 (solute carrier family 38 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 579.0), Muscle (RPKM 513.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q35

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (129730450..129742619, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (127851267..127863482, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (138088654..138100869, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Treatment with glutamine and its combination with liraglutide significantly increased pancreatic expression of SNAT2 by approximately 30-35 folds.
Title: Glutamine up-regulates pancreatic sodium-dependent neutral aminoacid transporter-2 and mitigates islets apoptosis in diabetic rats.
results show that SNAT2 contains 11 transmembrane domains (TMDs) with an intracellular N terminus and an extracellular C terminus
Title: Membrane topology of rat sodium-coupled neutral amino acid transporter 2 (SNAT2).
Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming
Title: Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.
there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function
Title: Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification.
These results suggested that Astragalus polysacchrides could improve muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling, and SLC38A2 may be one of potential targets.
Title: Astragalus polysaccharides decrease muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling in 5/6 nephrectomised rats.
The results suggest an important role of glutamine transport via SNAT2 in dendritic cells migration and a possible interaction between SNAT2 and CXCR4, by which Toxoplasma gondii manipulates host cell motility.
Title: Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways.
Prolactin actively supports lactation providing amino acids to the gland through SNAT2 for the synthesis of milk proteins.
Title: Prolactin and the dietary protein/carbohydrate ratio regulate the expression of SNAT2 amino acid transporter in the mammary gland during lactation.
Determination of SNAT2 mRNA levels by real-time PCR may be useful for estimating wound age.
Title: Time-dependent expression of SNAT2 mRNA in the contused skeletal muscle of rats: a possible marker for wound age estimation.
The mechanism by which 17beta-estradiol regulates the transcription of SNAT2, was elucidated.
Title: Transcriptional regulation of the sodium-coupled neutral amino acid transporter (SNAT2) by 17β-estradiol.
Sodium-coupled neutral amino acid transporter 2 (SNAT2) mRNA was also induced by the exercise in three muscles
Title: Induction of amino acid transporters expression by endurance exercise in rat skeletal muscle.

Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-glutamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables acidic amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables alanine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables proline:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-glutamine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-proline import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-serine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-serine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in acidic amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in alanine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid import	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to arsenite(3-)	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in glutamine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in glycine betaine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in proline transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate secretion, neurotransmission	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sodium-coupled neutral amino acid symporter 2

Names: amino acid transporter A2; amino acid transporter cationic 2; amino acid transporter system A2; amino acid transporter, cationic 2 (low affinity); sodium-coupled neutral amino acid transporter 2; system A amino acid transporter 2; system A transporter 1; system N amino acid transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181090.3 → NP_851604.2 sodium-coupled neutral amino acid symporter 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q9JHE5, Q9JI88

UniProtKB/TrEMBL

A6KC25

Related

ENSRNOP00000031532.2, ENSRNOT00000039002.4

Conserved Domains (1) summary

cl00456
Location:69 → 487

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain