Aqp1 aquaporin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aqp1provided by RGD
Official Full Name: aquaporin 1provided by RGD
Primary source: RGD:2141
See related: Ensembl:ENSRNOG00000011648 AllianceGenome:RGD:2141
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CHIP28
Summary: Enables glycerol transmembrane transporter activity and water channel activity. Involved in several processes, including glycerol transport; lateral ventricle development; and positive regulation of lamellipodium assembly. Located in several cellular components, including basolateral plasma membrane; brush border; and neuronal cell body membrane. Biomarker of artery disease (multiple); autosomal recessive polycystic kidney disease; brain disease (multiple); diabetes mellitus; and uveitis. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 2961.8), Lung (RPKM 899.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (85812784..85824964)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84482512..84494690)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85551503..85563683)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension.
Title: Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension.
Testicular AQP1 expression in a rat model of testicular Ischemia-Reperfusion injury.
Title: Testicular AQP1 expression in a rat model of testicular Ischemia-Reperfusion injury.
Differential response of cardiac aquaporins to hyperosmotic stress; salutary role of AQP1 against the induced apoptosis.
Title: Differential response of cardiac aquaporins to hyperosmotic stress; salutary role of AQP1 against the induced apoptosis.
AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.
Title: AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.
Aldosterone Contributed to Pulmonary Arterial Hypertension Development via Stimulating Aquaporin Expression and Pulmonary Arterial Smooth Muscle Cells Proliferation.
Title: Aldosterone Contributed to Pulmonary Arterial Hypertension Development via Stimulating Aquaporin Expression and Pulmonary Arterial Smooth Muscle Cells Proliferation.
Effect of cGMP-activated aquaporin 1 on TRPV4 in rats with allodynia induced by chronic compression of the dorsal root ganglion.
Title: Effect of cGMP-activated aquaporin 1 on TRPV4 in rats with allodynia induced by chronic compression of the dorsal root ganglion.
Aquaporin 1 alleviates acute kidney injury via PI3K-mediated macrophage M2 polarization.
Title: Aquaporin 1 alleviates acute kidney injury via PI3K-mediated macrophage M2 polarization.
We demonstrated that AQP1 plays a protective role in modulating acute renal injury.
Title: Aquaporin-1 attenuates macrophage-mediated inflammatory responses by inhibiting p38 mitogen-activated protein kinase activation in lipopolysaccharide-induced acute kidney injury.
AQP1 and AQP4 are remarkably correlated with the severity of hydrocephalus induced by subarachnoid hemorrhage.
Title: The dynamic expression of aquaporins 1 and 4 in rats with hydrocephalus induced by subarachnoid haemorrhage.
Study demonstrated for the first time that AQP1 and AQP4 were involved in the cerebral edema caused by acute CO exposure in rat models, and p38 MAPK inhibitor, SB203580 effectively reduced cerebral edema and alleviated associated AQP1 and AQP4 up-regulation, suggesting the manipulation of AQP1 and AQP4 could be another "downstream-targeting" treatment of acute CO poisoning.
Title: Involvement of p38 mitogen-activated protein kinase in altered expressions of AQP1 and AQP4 after carbon monoxide poisoning in rat astrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aqp1 (e-PCR), detects polymorphism
- UniSTS:186490

RH127574 (e-PCR)
- UniSTS:210884

Aqp1 (e-PCR), detects polymorphism
- UniSTS:530941

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ammonium transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ammonium transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbon dioxide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbon dioxide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables glycerol transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables nitric oxide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nitric oxide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables water transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ammonium transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbon dioxide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbon dioxide transport	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular hyperosmotic response	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to copper ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to inorganic substance	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mercury ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mercury ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nitric oxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to salt stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to salt stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebrospinal fluid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of actin cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of actin cytoskeleton polarity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in hyperosmotic response	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyperosmotic response	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lateral ventricle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lateral ventricle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid digestion	ISO Inferred from Sequence Orthology more info
involved_in metanephric descending thin limb development	ISO Inferred from Sequence Orthology more info
involved_in metanephric glomerulus vasculature development	ISO Inferred from Sequence Orthology more info
involved_in metanephric proximal convoluted tubule segment 2 development	ISO Inferred from Sequence Orthology more info
involved_in metanephric proximal straight tubule development	ISO Inferred from Sequence Orthology more info
involved_in metanephric proximal tubule development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nitric oxide transport	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of saliva secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal water absorption	ISO Inferred from Sequence Orthology more info
involved_in renal water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in renal water transport	ISO Inferred from Sequence Orthology more info
involved_in renal water transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within secretion by cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secretory granule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in transepithelial water transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial water transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in water transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ankyrin-1 complex	ISO Inferred from Sequence Orthology more info
part_of ankyrin-1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
NOT located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: aquaporin-1

Names: AQP-1; Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP)); aquaporin 1 (Colton blood group); aquaporin-CHIP; water channel protein for red blood cells and kidney proximal tubule

NP_036910.1

EC 2.7.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.