Aacs acetoacetyl-CoA synthetase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aacsprovided by RGD
Official Full Name: acetoacetyl-CoA synthetaseprovided by RGD
Primary source: RGD:708522
See related: Ensembl:ENSRNOG00000000967 AllianceGenome:RGD:708522
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables acetoacetate-CoA ligase activity and butyrate-CoA ligase activity. Involved in several processes, including cellular response to glucose stimulus; cellular response to lipid; and positive regulation of insulin secretion. Located in cytosol. Biomarker of obesity. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 195.5), Brain (RPKM 119.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (36774471..36817835, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (31113098..31156411, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (36512393..36555694, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prenatal nicotine exposure can cause DNA hypermethylation of the AACS promoter in the rat fetal adrenal.
Title: DNA hypermethylation of acetoacetyl-CoA synthetase contributes to inhibited cholesterol supply and steroidogenesis in fetal rat adrenals under prenatal nicotine exposure.
As acetoacetyl-CoA synthetase was expressed in neural-like cells, ketone bodies are assumed to be utilized for the synthesis of lipidic substances and to cause metabolic disorders in the nervous system of genetically obese rats.
Title: Genetic obesity affects neural ketone body utilization in the rat brain.
AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development
Title: Acetoacetyl-CoA synthetase gene is abundant in rat adipose, and related with fatty acid synthesis in mature adipocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetoacetate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetoacetate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetoacetate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables acetoacetate-CoA ligase activity	NAS Non-traceable Author Statement more info	PubMed
enables short-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adipose tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in liver development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oleic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to purine-containing compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in white fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetoacetyl-CoA synthetase

Names: AcAc-CoA ligase; acetoacetate-CoA ligase; acetoacetyl-CoA ligase

NP_075592.1

EC 6.2.1.16

XP_038945669.1

EC 6.2.1.16

XP_063127716.1

EC 6.2.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023104.2 → NP_075592.1 acetoacetyl-CoA synthetase

See identical proteins and their annotated locations for NP_075592.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q9JMI1

UniProtKB/TrEMBL

A0A8I5ZR35, A6J0W1

Related

ENSRNOP00000001292.3, ENSRNOT00000001292.6

Conserved Domains (1) summary

TIGR01217
Location:16 → 671

ac_ac_CoA_syn; acetoacetyl-CoA synthase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

36774471..36817835 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271646.1 → XP_063127716.1 acetoacetyl-CoA synthetase isoform X2
XM_039089741.2 → XP_038945669.1 acetoacetyl-CoA synthetase isoform X1

Conserved Domains (1) summary

TIGR01217
Location:1 → 527

ac_ac_CoA_syn; acetoacetyl-CoA synthase