Gast gastrin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gastprovided by RGD
Official Full Name: gastrinprovided by RGD
Primary source: RGD:2662
See related: Ensembl:ENSRNOG00000014740 AllianceGenome:RGD:2662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gas; PPG34
Summary: Enables hormone activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be active in extracellular space. Orthologous to human GAST (gastrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (85765216..85767881)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85264832..85269393)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88245532..88248485)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gastrin: a new branch of the gastropancreatic axis that can explain the effect of sleeve gastrectomy on glucose metabolism.
Title: Gastrin: a new branch of the gastropancreatic axis that can explain the effect of sleeve gastrectomy on glucose metabolism.
we examined the chronic effects of a GLP-1-gastrin dual agonist ZP3022 on glycemic control and beta cell dysfunction in overtly diabetic Zucker Diabetic Fatty
Title: The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats.
treatment with gastrin, a CCK2R agonist, stimulated the secretion of GLP-1, and that this effect was likely due to increased expression of proglucagon and PCSK1 (also known as prohormone convertase 3 (PC3 gene)).
Title: Expression of cholecystokinin2-receptor in rat and human L cells and the stimulation of glucagon-like peptide-1 secretion by gastrin treatment.
The results suggested that clusterin may contribute to gastrin's growth-promoting effect on the oxyntic mucosa.
Title: Gastrin upregulates the prosurvival factor secretory clusterin in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats.
G cells are luminal sampling chemomechanosensory cells whose gastrin secretion is regulated by neural, hormonal, luminal, and mechanical factors through protein kinase A activation, cAMP signaling, and mitogen-activated protein kinase phosphorylation.
Title: Delineation of the chemomechanosensory regulation of gastrin secretion using pure rodent G cells.
the role of JAK-dependent pathways in the regulation of E-cadherin-dependent cell-cell adhesion by gastrin
Title: Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin.
role in increasing expression of COX-2 mRNA and protein, the activity of the COX-2 promoter, and the release of prostaglandin E(2)
Title: Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor.
gastrin induces Akt through activation of CCKB receptors and of intracellular calcium-dependent, PKC-independent, pathways
Title: Intracellular mechanisms mediating the anti-apoptotic action of gastrin.
GIP, GLP-1, insulin and gastrin have roles in ghrelin release in the isolated rat stomach
Title: Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach.
plays a role in the development of gastric mucosa, ECL cells and A-like cells in newborn and young rats
Title: Role of gastrin in the development of gastric mucosa, ECL cells and A-like cells in newborn and young rats.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in response to food	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gastrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012849.1 → NP_036981.1 gastrin precursor

See identical proteins and their annotated locations for NP_036981.1

Status: PROVISIONAL

Source sequence(s)

M38653

UniProtKB/Swiss-Prot

P04563

UniProtKB/TrEMBL

A6HJ25

Related

ENSRNOP00000019863.1, ENSRNOT00000019863.3

Conserved Domains (1) summary

cl27628
Location:4 → 101

Gastrin; Gastrin/cholecystokinin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

85765216..85767881

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597037.3 → XP_017452526.1 gastrin isoform X1

UniProtKB/Swiss-Prot

P04563

UniProtKB/TrEMBL

A6HJ25

Conserved Domains (1) summary

cl27628
Location:4 → 101

Gastrin; Gastrin/cholecystokinin family