Emb embigin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Embprovided by RGD
Official Full Name: embiginprovided by RGD
Primary source: RGD:621067
See related: Ensembl:ENSRNOG00000060329 AllianceGenome:RGD:621067
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cell-cell adhesion mediator activity. Involved in cell adhesion and plasma membrane lactate transport. Is integral component of plasma membrane. Orthologous to human EMB (embigin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 457.6), Thymus (RPKM 206.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (50803468..50858001)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (49070509..49125042)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (49682763..49733475)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study analyzed the direct interaction between CAIV and the two Monocarboxylate transporters (MCTs) chaperones basigin (CD147) and embigin (GP70).
Title: Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70.
Expression of active MCT2 at the plasma membrane of oocytes was significantly enhanced by co-expression of exogenous embigin.
Title: The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein.
embigin enhances neural cell adhesion molecule-dependent neuromuscular adhesion and thereby modulates neuromuscular junction formation and plasticity.
Title: A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction.
MCT2 associates with gp70 and is insensitive to pCMBS; embigin (gp70) is an ancillary protein required to maintain the catalytic activity of MCT2
Title: Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane lactate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane lactate transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: embigin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053719.1 → NP_446171.1 embigin precursor

See identical proteins and their annotated locations for NP_446171.1

Status: PROVISIONAL

Source sequence(s)

AJ009698

UniProtKB/Swiss-Prot

O88775

UniProtKB/TrEMBL

A0A0G2JWP4, A6I5U2

Related

ENSRNOP00000069959.2, ENSRNOT00000085576.2

Conserved Domains (3) summary

cd00096
Location:177 → 252

Ig; Immunoglobulin domain

smart00410
Location:172 → 255

IG_like; Immunoglobulin like

pfam07679
Location:84 → 144

I-set; Immunoglobulin I-set domain