Rasa3 RAS p21 protein activator 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rasa3provided by RGD
Official Full Name: RAS p21 protein activator 3provided by RGD
Primary source: RGD:69365
See related: Ensembl:ENSRNOG00000017671 AllianceGenome:RGD:69365
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: R-ras gap
Summary: Predicted to enable calcium-release channel activity. Acts upstream of or within cellular response to heat. Predicted to be intrinsic component of the cytoplasmic side of the plasma membrane. Orthologous to human RASA3 (RAS p21 protein activator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 348.0), Brain (RPKM 159.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (82557556..82671527)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (75855360..75969349)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (81320090..81434239, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

novel mechanism for dopamine D2S-induced inhibition of ERK1/2 and indicate that RASA3 links Galphai proteins to inhibit Gq-induced Ras/ERK1/2 activation.
Title: GAP1(IP4BP)/RASA3 mediates Galphai-induced inhibition of mitogen-activated protein kinase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Got107 (e-PCR)
- UniSTS:111735

BF386157 (e-PCR)
- UniSTS:243595

D16Wox25 (e-PCR)
- UniSTS:518841

RH139547 (e-PCR)
- UniSTS:221632

D16Got83 (e-PCR)
- UniSTS:111811

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables intracellularly gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras GTPase-activating protein 3

Names: GAP1(IP4BP); Ins P4-binding protein; R-Ras GTP activating protein; R-ras GTPase activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031574.1 → NP_113762.1 ras GTPase-activating protein 3

See identical proteins and their annotated locations for NP_113762.1

Status: PROVISIONAL

Source sequence(s)

D86045

UniProtKB/Swiss-Prot

Q09YN9, Q9QYJ2

UniProtKB/TrEMBL

A0A0G2JW85

Related

ENSRNOP00000069783.1, ENSRNOT00000080963.3

Conserved Domains (7) summary

smart00107
Location:679 → 714

BTK; Bruton's tyrosine kinase Cys-rich motif

cd04010
Location:146 → 288

C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)

cd08401
Location:13 → 133

C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3

cd05134
Location:297 → 565

RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3

smart00323
Location:276 → 614

RasGAP; GTPase-activator protein for Ras-like GTPases

cd13371
Location:562 → 686

PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain

pfam00169
Location:577 → 676

PH; PH domain