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    Paox polyamine oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293589, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Paoxprovided by RGD
    Official Full Name
    polyamine oxidaseprovided by RGD
    Primary source
    RGD:1561125
    See related
    Ensembl:ENSRNOG00000018838 AllianceGenome:RGD:1561125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables polyamine oxidase activity. Involved in putrescine catabolic process; spermidine catabolic process; and spermine catabolic process. Located in peroxisomal matrix. Orthologous to human PAOX (polyamine oxidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 118.7), Kidney (RPKM 82.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Paox in Genome Data Viewer
    Location:
    1q41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (204349326..204358140)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194919655..194928498)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (212578444..212603722)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene uncharacterized LOC134485198 Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene shadow of prion protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dexamethasone decreases the spermidine and spermine concentrations and polyamine oxidase activity in rat thymus. Bjelaković G, et al. J Basic Clin Physiol Pharmacol, 2013. PMID 23425626
    2. In situ substrate specificity and ultrastructural localization of polyamine oxidase activity in unfixed rat tissues. Van den Munckhof RJ, et al. J Histochem Cytochem, 1995 Nov. PMID 7560898
    3. Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats. Gudkova OO, et al. Ukr Biochem J, 2016 Jan-Feb. PMID 29227084
    4. Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase. Järvinen A, et al. J Biol Chem, 2006 Feb 24. PMID 16354669
    5. Effect of mitoguazone on polyamine oxidase activity in rat liver. Ferioli ME, et al. Toxicol Appl Pharmacol, 2004 Dec 1. PMID 15541750

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Amine oxidases are important mediators of pathological processes of rhabdomyolysis in rats.
      Title: Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables polyamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in polyamine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within polyamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of spermidine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in putrescine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in putrescine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in putrescine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermidine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in peroxisomal matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisomal N(1)-acetyl-spermine/spermidine oxidase
    Names
    GTP-binding protein-like
    polyamine oxidase (exo-N4-amino)
    putative GTP-binding protein
    NP_001385701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398772.1 → NP_001385701.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AEP5, A6HXH1
      Related
      ENSRNOP00000091101.1, ENSRNOT00000098933.1
      Conserved Domains (1) summary
      PLN02568
      Location:1 → 489
      PLN02568; polyamine oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      204349326..204358140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106311.1: Suppressed sequence

      Description
      NM_001106311.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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