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    Sgca sarcoglycan, alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303468, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Sgcaprovided by RGD
    Official Full Name
    sarcoglycan, alphaprovided by RGD
    Primary source
    RGD:1308062
    See related
    Ensembl:ENSRNOG00000003998 AllianceGenome:RGD:1308062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Involved in response to denervation involved in regulation of muscle adaptation and skeletal muscle tissue regeneration. Predicted to be located in cell-cell junction; membrane raft; and sarcolemma. Predicted to be part of sarcoglycan complex. Biomarker of muscular atrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2D and muscular dystrophy. Orthologous to human SGCA (sarcoglycan alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 401.0), Muscle (RPKM 395.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgca in Genome Data Viewer
    Location:
    10q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (80397158..80416165, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79904698..79922808, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (82770905..82785142, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase D, pseudogene 13 Neighboring gene uncharacterized LOC102556395 Neighboring gene collagen type I alpha 1 chain Neighboring gene uncharacterized LOC102557019 Neighboring gene histone linker H1 domain, spermatid-specific 1 Neighboring gene protein phosphatase 1, regulatory subunit 9B Neighboring gene sterile alpha motif domain containing 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Long-term skeletal muscle protection after gene transfer in a mouse model of LGMD-2D. Pacak CA, et al. Mol Ther, 2007 Oct. PMID 17653106
    2. Mutational diversity and hot spots in the alpha-sarcoglycan gene in autosomal recessive muscular dystrophy (LGMD2D). Carrié A, et al. J Med Genet, 1997 Jun. PMID 9192266, Free PMC Article
    3. Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy. Roberds SL, et al. Cell, 1994 Aug 26. PMID 8069911
    4. The expression of dystrophin, alpha-sarcoglycan, and beta-dystroglycan during skeletal muscle regeneration: immunohistochemical and western blot studies. Hoshino S, et al. Acta Histochem, 2002. PMID 12086334
    5. Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice. Duclos F, et al. J Cell Biol, 1998 Sep 21. PMID 9744877, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In cerebellar neurons and glial cells alpha-, beta-, gamma-, delta-, and epsilon-sarcoglycans are all expressed.
      Title: Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex.
    2. expression of alpha-sarcoglycan (Sgca)during skeletal muscle regeneration.
      Title: The expression of dystrophin, alpha-sarcoglycan, and beta-dystroglycan during skeletal muscle regeneration: immunohistochemical and western blot studies.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to denervation involved in regulation of muscle adaptation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in skeletal muscle tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dystroglycan complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sarcoglycan complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-sarcoglycan
    Names
    adhalin
    sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
    sarcoglycan, alpha (dystrophin-associated glycoprotein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107039.2 → NP_001100509.1  alpha-sarcoglycan isoform 1 precursor

      See identical proteins and their annotated locations for NP_001100509.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y0I5, A6HI73, D3ZDQ9
      Related
      ENSRNOP00000005381.4, ENSRNOT00000005381.7
      Conserved Domains (1) summary
      pfam05510
      Location:27 → 347
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    2. NM_001395600.1 → NP_001382529.1  alpha-sarcoglycan isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y0I5
      Conserved Domains (1) summary
      pfam05510
      Location:9 → 291
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    3. NM_001395601.1 → NP_001382530.1  alpha-sarcoglycan isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Conserved Domains (1) summary
      pfam05510
      Location:12 → 254
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      80397158..80416165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086059.2 → XP_038941987.1  alpha-sarcoglycan isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0I5, A6HI73, D3ZDQ9
      Conserved Domains (1) summary
      pfam05510
      Location:27 → 347
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    2. XM_039086060.2 → XP_038941988.1  alpha-sarcoglycan isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0I5
      Conserved Domains (1) summary
      pfam05510
      Location:20 → 340
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    RNA

    1. XR_010055187.1 RNA Sequence

    2. XR_005489851.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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