Manf mesencephalic astrocyte-derived neurotrophic factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Manfprovided by RGD
Official Full Name: mesencephalic astrocyte-derived neurotrophic factorprovided by RGD
Primary source: RGD:1307252
See related: AllianceGenome:RGD:1307252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Armet
Summary: Predicted to enable sulfatide binding activity. Predicted to be involved in dopaminergic neuron differentiation; neuron projection development; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Located in extracellular space and perinuclear region of cytoplasm. Colocalizes with endoplasmic reticulum. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 506.7), Heart (RPKM 330.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (116427053..116430259, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (107500856..107551595, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (115623175..115626408, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen.
Title: Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen.
DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke.
Title: DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke.
Functional analysis of mesencephalic astrocyte-derived neurotrophic factor in retinal ganglion cells under oxidative stress.
Title: Functional analysis of mesencephalic astrocyte-derived neurotrophic factor in retinal ganglion cells under oxidative stress.
Mesencephalic astrocyte-derived neurotrophic factor showed not only transient but also long-lasting neuroprotective properties
Title: Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood-brain barrier integrity.
MANF is developmentally regulated and may play a role in the maturation of the central nervous system.
Title: Spatiotemporal expression of MANF in the developing rat brain.
The results of this study indicated that MANF expression was upregulated in the activated glial cells, which may contribute to the mechanism of ischemia-induced neural injury.
Title: Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation.
MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface.
Title: Mesencephalic astrocyte-derived neurotrophic factor (MANF) secretion and cell surface binding are modulated by KDEL receptors.
sarcoplasmic/endoplasmic reticulum calcium depletion triggered MANF secretion by decreasing its retention
Title: Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.
MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
Title: Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.
These results suggest that cerebral ischemia-induced ARMET expression may be protective to the neurons
Title: Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI144800 (e-PCR)
- UniSTS:245022

RH129214 (e-PCR)
- UniSTS:212522

D17914 (e-PCR)
- UniSTS:124739

RH125717 (e-PCR)
- UniSTS:162480

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables sulfatide binding	IEA Inferred from Electronic Annotation more info
enables sulfatide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in dopaminergic neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mesencephalic astrocyte-derived neurotrophic factor

Names: arginine-rich protein; arginine-rich, mutated in early stage tumors

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401064.1 → NP_001387993.1 mesencephalic astrocyte-derived neurotrophic factor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P0C5H9

UniProtKB/TrEMBL

A0A8L2Q9K9, B2RZ09

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

116427053..116430259 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108183.1: Suppressed sequence

Description

NM_001108183.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.