Afap1l1 actin filament associated protein 1-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Afap1l1provided by RGD
Official Full Name: actin filament associated protein 1-like 1provided by RGD
Primary source: RGD:1311580
See related: Ensembl:ENSRNOG00000019403 AllianceGenome:RGD:1311580
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311580
Summary: Predicted to enable SH3 domain binding activity. Predicted to be located in cell junction; cell projection; and podosome. Predicted to be active in cytosol. Orthologous to human AFAP1L1 (actin filament associated protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 193.0), Heart (RPKM 128.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (57454120..57514584, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (55183786..55244174, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (57052659..57114589, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI173486 (e-PCR)
- UniSTS:181132

RH144646 (e-PCR)
- UniSTS:233891

RH139549 (e-PCR)
- UniSTS:221634

RH136781 (e-PCR)
- UniSTS:218870

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: actin filament-associated protein 1-like 1

Names: AFAP1-like protein 1; actin filament-associated protein, 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106142.1 → NP_001099612.1 actin filament-associated protein 1-like 1

See identical proteins and their annotated locations for NP_001099612.1

Status: PROVISIONAL

Source sequence(s)

CH473971

UniProtKB/Swiss-Prot

D4AB98

UniProtKB/TrEMBL

A0A8I6AWR7

Related

ENSRNOP00000026495.5, ENSRNOT00000026495.5

Conserved Domains (3) summary

cd13306
Location:209 → 314

PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1

cd13307
Location:418 → 517

PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:225 → 315

PH; PH domain