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    Nsun4 NOP2/Sun RNA methyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298426, updated on 9-Mar-2024

    Summary

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    Symbol
    Nsun4provided by RGD
    Full Name
    NOP2/Sun RNA methyltransferase 4provided by RGD
    Primary source
    RGD:1559652
    See related
    Ensembl:ENSRNOG00000012020 AllianceGenome:RGD:1559652
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559652
    Summary
    Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity and small ribosomal subunit rRNA binding activity. Predicted to be involved in mature ribosome assembly; positive regulation of mitochondrial translation; and rRNA methylation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 113.1), Muscle (RPKM 81.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsun4 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134749024..134773630, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129511224..129532498, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134885377..134905492, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene diencephalon/mesencephalon homeobox 1 Neighboring gene fatty acid amide hydrolase Neighboring gene uncharacterized LOC134486970 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene leucine rich repeat containing 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification. Yakubovskaya E, et al. Structure, 2012 Nov 7. PMID 23022348, Free PMC Article
    2. NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly. Metodiev MD, et al. PLoS Genet, 2014 Feb. PMID 24516400, Free PMC Article
    3. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cámara Y, et al. Cell Metab, 2011 May 4. PMID 21531335
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small ribosomal subunit rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytosolic ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    5-methylcytosine rRNA methyltransferase NSUN4
    Names
    NOL1/NOP2/Sun domain family, member 4
    NOP2/Sun RNA methyltransferase family member 4
    NOP2/Sun domain family, member 4
    NP_001100148.1
    XP_038965521.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106678.1 → NP_001100148.1  5-methylcytosine rRNA methyltransferase NSUN4

      See identical proteins and their annotated locations for NP_001100148.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474008
      UniProtKB/TrEMBL
      A6JZ58, D4A099, D4A5A7
      Related
      ENSRNOP00000016714.4, ENSRNOT00000016714.6
      Conserved Domains (1) summary
      cl17173
      Location:163 → 322
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      134749024..134773630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109593.2 → XP_038965521.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform X1

      Conserved Domains (1) summary
      TIGR00446
      Location:3 → 174
      nop2p; NOL1/NOP2/sun family putative RNA methylase
    Nucleotide Protein Strain
    Heading Accession and Version

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