Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdk2ap2provided by RGD
Official Full Name: cyclin-dependent kinase 2 associated protein 2provided by RGD
Primary source: RGD:1588883
See related: Ensembl:ENSRNOG00000018391 AllianceGenome:RGD:1588883
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle; regulation of microtubule cytoskeleton organization; and regulation of stem cell division. Predicted to be active in cytoplasm; microtubule; and nucleus. Orthologous to human CDK2AP2 (cyclin dependent kinase 2 associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 243.5), Kidney (RPKM 196.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (210819155..210822604)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (201391056..201393137)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (219345638..219347709)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of stem cell division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase 2-associated protein 2

Names: CDK2-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109498.1 → NP_001102968.1 cyclin-dependent kinase 2-associated protein 2

See identical proteins and their annotated locations for NP_001102968.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A0A8I6AG30, A6HYS8, A6HYS9, D4A033

Related

ENSRNOP00000025018.2, ENSRNOT00000025018.5

Conserved Domains (2) summary

TIGR00601
Location:5 → 107

rad23; UV excision repair protein Rad23

pfam09806
Location:63 → 126

CDK2AP; Cyclin-dependent kinase 2-associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

210819155..210822604

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230902.5 → XP_006230964.1 cyclin-dependent kinase 2-associated protein 2 isoform X1

See identical proteins and their annotated locations for XP_006230964.1

UniProtKB/TrEMBL

A0A8I6AG30, A6HYS7, A6HYS9

Conserved Domains (2) summary

pfam07462
Location:7 → 40

MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus

pfam09806
Location:74 → 107

CDK2AP; Cyclin-dependent kinase 2-associated protein