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    Cog1 component of oligomeric golgi complex 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303652, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Cog1provided by RGD
    Official Full Name
    component of oligomeric golgi complex 1provided by RGD
    Primary source
    RGD:1304594
    See related
    Ensembl:ENSRNOG00000002795 AllianceGenome:RGD:1304594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intra-Golgi vesicle-mediated transport and protein transport. Predicted to be located in membrane. Predicted to be part of Golgi transport complex. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Orthologous to human COG1 (component of oligomeric golgi complex 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 104.3), Adrenal (RPKM 98.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cog1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (99192604..99207640)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (98695481..98708495)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (102167594..102180569)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39, member 11 Neighboring gene transfer RNA alanine (anticodon UGC) 10 Neighboring gene somatostatin receptor 2 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. Ungar D, et al. J Cell Biol, 2002 Apr 29. PMID 11980916, Free PMC Article
    2. The binary interacting network of the conserved oligomeric Golgi tethering complex. Loh E, et al. J Biol Chem, 2004 Jun 4. PMID 15047703
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    conserved oligomeric Golgi complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107062.2 → NP_001100532.2  conserved oligomeric Golgi complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      B5DFI1
      Related
      ENSRNOP00000091572.1, ENSRNOT00000113311.1
      Conserved Domains (1) summary
      pfam08700
      Location:17 → 91
      Vps51; Vps51/Vps67

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      99192604..99207640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269227.1 → XP_063125297.1  conserved oligomeric Golgi complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AFV4, F1LND1

    RNA

    1. XR_005489864.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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