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    Tubgcp4 tubulin gamma complex component 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362203, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tubgcp4provided by RGD
    Official Full Name
    tubulin gamma complex component 4provided by RGD
    Primary source
    RGD:1306924
    See related
    Ensembl:ENSRNOG00000012798 AllianceGenome:RGD:1306924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306924
    Summary
    Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in recycling endosome. Predicted to be part of gamma-tubulin complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 3. Orthologous to human TUBGCP4 (tubulin gamma complex associated protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 106.5), Brain (RPKM 99.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tubgcp4 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128594052..128628789)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108141081..108172207)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113131292..113160750)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase-like Neighboring gene zinc finger and SCAN domain containing 29, pseudogene 1 Neighboring gene tumor protein p53 binding protein 1 Neighboring gene microtubule-associated protein 1A Neighboring gene diphosphoinositol pentakisphosphate kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab11 endosomes contribute to mitotic spindle organization and orientation. Hehnly H, et al. Dev Cell, 2014 Mar 10. PMID 24561039, Free PMC Article
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in equatorial microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex component 4
    Names
    tubulin, gamma complex associated protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399280.1 → NP_001386209.1  gamma-tubulin complex component 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPM6
      Conserved Domains (2) summary
      pfam04130
      Location:350 → 655
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:2 → 347
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    2. NM_001399282.1 → NP_001386211.1  gamma-tubulin complex component 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6GK03
      Related
      ENSRNOP00000092022.1, ENSRNOT00000115059.1
      Conserved Domains (2) summary
      pfam04130
      Location:350 → 654
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:2 → 347
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128594052..128628789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106529.2 → XP_038962457.1  gamma-tubulin complex component 4 isoform X1

      UniProtKB/TrEMBL
      D3ZVR0
      Conserved Domains (2) summary
      pfam04130
      Location:339 → 644
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:2 → 336
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    2. XM_063284163.1 → XP_063140233.1  gamma-tubulin complex component 4 isoform X2

    3. XM_039106531.2 → XP_038962459.1  gamma-tubulin complex component 4 isoform X4

      Conserved Domains (2) summary
      pfam04130
      Location:350 → 474
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:2 → 347
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    4. XM_039106532.2 → XP_038962460.1  gamma-tubulin complex component 4 isoform X5

      Conserved Domains (1) summary
      pfam17681
      Location:2 → 286
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    5. XM_039106530.1 → XP_038962458.1  gamma-tubulin complex component 4 isoform X3

      Conserved Domains (2) summary
      pfam04130
      Location:214 → 519
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:2 → 211
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RNA

    1. XR_010064663.1 RNA Sequence

    2. XR_005502399.2 RNA Sequence

    3. XR_001837217.3 RNA Sequence

    4. XR_010064664.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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