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    Nim1k NIM1 serine/threonine protein kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310376, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Nim1kprovided by RGD
    Official Full Name
    NIM1 serine/threonine protein kinaseprovided by RGD
    Primary source
    RGD:1308116
    See related
    Ensembl:ENSRNOG00000016353 AllianceGenome:RGD:1308116
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nim1; RGD1308116
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in cellular response to glucose starvation; intracellular signal transduction; and protein phosphorylation. Orthologous to human NIM1K (NIM1 serine/threonine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 30.9), Liver (RPKM 11.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nim1k in Genome Data Viewer
    Location:
    2q15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (53403467..53451248, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (51670764..51714782, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (52448746..52494137, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547360 Neighboring gene C-C motif chemokine ligand 28 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 1 Neighboring gene uncharacterized LOC134485849 Neighboring gene zinc finger protein 131 Neighboring gene RNA, U6 small nuclear 446

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. Jaleel M, et al. FEBS Lett, 2005 Feb 28. PMID 15733851
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase NIM1
    XP_006232044.1
    XP_038959451.1
    XP_063138911.1
    XP_063138912.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      53403467..53451248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231982.5 → XP_006232044.1  serine/threonine-protein kinase NIM1 isoform X1

      See identical proteins and their annotated locations for XP_006232044.1

      UniProtKB/TrEMBL
      D4A9H8
      Related
      ENSRNOP00000021964.3
      Conserved Domains (1) summary
      cd14075
      Location:71 → 325
      STKc_NIM1; Catalytic domain of the Serine/Threonine Kinase, NIM1

    2. XM_039103523.2 → XP_038959451.1  serine/threonine-protein kinase NIM1 isoform X1

      UniProtKB/TrEMBL
      D4A9H8
      Conserved Domains (1) summary
      cd14075
      Location:71 → 325
      STKc_NIM1; Catalytic domain of the Serine/Threonine Kinase, NIM1

    3. XM_063282842.1 → XP_063138912.1  serine/threonine-protein kinase NIM1 isoform X2

      UniProtKB/TrEMBL
      A6I5X0

    4. XM_063282841.1 → XP_063138911.1  serine/threonine-protein kinase NIM1 isoform X1

      UniProtKB/TrEMBL
      D4A9H8
    Nucleotide Protein Strain
    Heading Accession and Version

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