Adap1 ArfGAP with dual PH domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adap1provided by RGD
Official Full Name: ArfGAP with dual PH domains 1provided by RGD
Primary source: RGD:621418
See related: Ensembl:ENSRNOG00000054033 AllianceGenome:RGD:621418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Centa1; p42IP4
Summary: Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of GTPase activity. Predicted to be located in cytosol; nucleus; and plasma membrane. Orthologous to human ADAP1 (ArfGAP with dual PH domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 207.2), Kidney (RPKM 46.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (20438091..20489961)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (15323913..15376110)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (17416327..17468212)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biotin labeling of cell surface proteins from cardiomyocytes overexpressing ADAP1 revealed that it reduces the surface expression of b1-integrin, an effect that is strongly potentiated by Mek1ca overexpression.
Title: ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression.
The CentA1-Ras-Elk-1 signaling pathway acts on mitochondria to regulate dendritic spine density and synaptic plasticity in response to Abeta in hippocampal neurons.
Title: Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction.
These data support the conclusion that centaurin alpha1 functions through GAP-dependent Arf regulation of dendritic branching and spines that underlie normal dendritic differentiation and development.
Title: The neuronal Arf GAP centaurin alpha1 modulates dendritic differentiation.
direct binding between centaurin-alpha(1) and KIF13B could concentrate centaurin-alpha(1) at the leading edges of cells, thus modulating ADP-ribosylation factor 6 function.
Title: Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B.
p42IP4, an adapter protein in PIP3-dependent cellular signaling, may play an important role in the signal transduction pathways regulating plasticity in neuronal cells.
Title: Short-term down-regulation of the brain-specific, PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding, adapter protein, p42IP4/centaurin-alpha 1 in rat brain after acoustic and electric stimulation.
Data suggest that oligomerization of inositol phosphate/phosphatidylinositol binding proteins such as cytoadhesin 1 and centaurin alpha 1 can modulate their function in a tissue-dependent manner.
Title: Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate.
p42(IP4) did not seem to be restricted to specific developmental stages, but the high absolute expression levels at all developmental stages indicated that p42(IP4) is a protein fundamental for neuronal functioning
Title: Expression of the brain-specific membrane adapter protein p42IP4/centaurin alpha, a Ins(1,3,4,5)P4/PtdIns(3,4,5)P3 binding protein, in developing rat brain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables inositol 1,3,4,5 tetrakisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arf-GAP with dual PH domain-containing protein 1

Names: centaurin, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133567.2 → NP_598251.1 arf-GAP with dual PH domain-containing protein 1

See identical proteins and their annotated locations for NP_598251.1

Status: VALIDATED

Source sequence(s)

BC099775

UniProtKB/TrEMBL

O88768, Q9QUI9

Related

ENSRNOP00000075236.1, ENSRNOT00000089590.2

Conserved Domains (3) summary

cd01251
Location:252 → 357

PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2

cd13252
Location:130 → 238

PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

cd08843
Location:4 → 113

ArfGap_ADAP1; ADAP1 GTPase activating protein for Arf, with dual PH domains