Ido1 indoleamine 2,3-dioxygenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ido1provided by RGD
Official Full Name: indoleamine 2,3-dioxygenase 1provided by RGD
Primary source: RGD:619989
See related: Ensembl:ENSRNOG00000031189 AllianceGenome:RGD:619989
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ido; Indo
Summary: Enables amino acid binding activity; indoleamine 2,3-dioxygenase activity; and oxygen binding activity. Involved in tryptophan catabolic process to kynurenine. Located in cytosol. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 11.8), Testes (RPKM 2.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (74133259..74145328)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (67430654..67442726)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (72216326..72228098)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of moderate-intensity continuous training and high-intensity interval training effects on the Ido1-KYN-Ahr axis in the heart tissue of rats with occlusion of the left anterior descending artery.
Title: Comparison of moderate-intensity continuous training and high-intensity interval training effects on the Ido1-KYN-Ahr axis in the heart tissue of rats with occlusion of the left anterior descending artery.
Parasite-versus-host interactions were observed on a model of neuron/glia co/cultures obtained from rat brains. Data indicate that iNOS, IDO and COX-2 control the proliferation of Neospora caninum in this in vitro model.
Title: IDO, COX and iNOS have an important role in the proliferation of Neospora caninum in neuron/glia co-cultures.
Results show the antidepressant effect of infliximab and suggest that its mechanism is partly related to inhibition of indoleamine 2, 3-dioxygenase/3-hydroxyl amino acid oxygenase pathway activation mediated by tumor necrosis factor-alpha in rat brain.
Title: Infliximab ameliorating depression-like behavior through inhibiting the activation of the IDO-HAAO pathway mediated by tumor necrosis factor-α in a rat model.
this study suggests a link between melatonin, JNK, FoxO1 and IDO1 that acts as a potential balance regulator of tryptophan metabolism, and offers a new approach to treat diseases related to dysregulation of tryptophan metabolism
Title: Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism.
results suggest that M30 is neuroprotective against CORT-induced depression targeting elevated MAO activities that cause oxidative stress and neuroinflammation, resulting in IDO-1 activation, serotonin deficiency and neurodegeneration.
Title: M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus.
activation of the MAPK and PI3K-AKT pathways primarily regulated Ser-727 phosphorylation, whereas a physical interaction between RET/PTC3 and STAT1, followed by a direct tyrosine phosphorylation event, was necessary for STAT1 Tyr-701 phosphorylation. These data provide the first evidence of a direct link between IDO1 expression and the oncogenic activation of RET in thyroid carcinoma
Title: Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.
IDO expression in NSCs synergistically potentiates the immune suppression activities of NSCs and could be applicable for the development of therapeutic modalities against various neurodegenerative diseases.
Title: The Synergistic Local Immunosuppressive Effects of Neural Stem Cells Expressing Indoleamine 2,3-Dioxygenase (IDO) in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model.
study demonstrates that IDO gene transfer into engineered lung allograft tissues significantly attenuates acute allograft damage suggesting local therapy with IDO as a strategy to reduce need for systemic immunosuppression and, thereby, its side effects
Title: Inducible expression of indoleamine 2,3-dioxygenase attenuates acute rejection of tissue-engineered lung allografts in rats.
Indoleamine 2,3-dioxygenase is upregulated in the brain of rats with acute pancreatitis.
Title: Indoleamine 2,3-dioxygenase is upregulated in the brain of rats with acute pancreatitis.
inhibitory effect of locally delivered CTLA4Ig is dependent on IDO activities within the allograft.
Title: Local cytotoxic T-lymphocyte-associated antigen-4 immunoglobulin inhibition of rejection response is dependent on indoleamine 2,3-dioxygenase activities in the allograft.

Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables indoleamine 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables indoleamine 2,3-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables indoleamine 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables indoleamine 2,3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables tryptophan 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' NAD biosynthetic process from tryptophan	IEA Inferred from Electronic Annotation more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in kynurenic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kynurenic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal response to stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell tolerance induction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell tolerance induction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chronic inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of chronic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in quinolinate biosynthetic process	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in swimming behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within swimming behavior	ISO Inferred from Sequence Orthology more info
involved_in tryptophan catabolic process to kynurenine	IBA Inferred from Biological aspect of Ancestor more info
involved_in tryptophan catabolic process to kynurenine	IDA Inferred from Direct Assay more info	PubMed
involved_in tryptophan catabolic process to kynurenine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tryptophan catabolic process to kynurenine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in smooth muscle contractile fiber	IEA Inferred from Electronic Annotation more info
located_in smooth muscle contractile fiber	ISO Inferred from Sequence Orthology more info
located_in stereocilium bundle	IEA Inferred from Electronic Annotation more info
located_in stereocilium bundle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: indoleamine 2,3-dioxygenase 1

Names: IDO-1; indoleamine 23-dioxygenase; indoleamine-pyrrole 2,3-dioxygenase

NP_076463.2

EC 1.13.11.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.