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    Cetn3 centrin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170895, updated on 13-Apr-2024

    Summary

    Symbol
    Cetn3provided by RGD
    Full Name
    centrin 3provided by RGD
    Primary source
    RGD:620249
    See related
    Ensembl:ENSRNOG00000050877 AllianceGenome:RGD:620249
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G-protein beta/gamma-subunit complex binding activity; calcium ion binding activity; and microtubule binding activity. Predicted to be located in microtubule organizing center and photoreceptor connecting cilium. Predicted to be part of nuclear pore nuclear basket and transcription export complex 2. Predicted to be active in microtubule organizing center. Orthologous to human CETN3 (centrin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 120.6), Heart (RPKM 98.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    Location:
    2q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (13817760..13837502)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (12089025..12101828)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (12101473..12115009)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene LysM domain containing 3 Neighboring gene RNA polymerase III subunit G Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene uncharacterized LOC134485813 Neighboring gene uncharacterized LOC108349914

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription export complex 2 ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centrin-3
    Names
    centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
    centrin-3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191842.1NP_001178771.1  centrin-3

      See identical proteins and their annotated locations for NP_001178771.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I4J2, Q91ZZ8
      Related
      ENSRNOP00000067453.2, ENSRNOT00000072155.2
      Conserved Domains (1) summary
      PTZ00183
      Location:15166
      PTZ00183; centrin; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      13817760..13837502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101606.2XP_038957534.1  centrin-3 isoform X2

      UniProtKB/TrEMBL
      G3V821, Q91ZZ8
      Related
      ENSRNOP00000064372.2
      Conserved Domains (1) summary
      PTZ00183
      Location:38189
      PTZ00183; centrin; Provisional
    2. XM_063281214.1XP_063137284.1  centrin-3 isoform X1

    3. XM_063281215.1XP_063137285.1  centrin-3 isoform X3