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    Rhobtb1 Rho-related BTB domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309722, updated on 3-Apr-2024

    Summary

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    Symbol
    Rhobtb1provided by RGD
    Full Name
    Rho-related BTB domain containing 1provided by RGD
    Primary source
    RGD:1306871
    See related
    Ensembl:ENSRNOG00000000633 AllianceGenome:RGD:1306871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and regulation of cell shape. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 163.6), Heart (RPKM 82.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhobtb1 in Genome Data Viewer
    Location:
    20p11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (19326197..19455182, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (19327142..19456121, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (20638579..20715437, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 1 Neighboring gene uncharacterized LOC102554932 Neighboring gene uncharacterized LOC120098936 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC120098858

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1. Xiao J, et al. Exp Mol Med, 2017 Oct 20. PMID 29053138, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho-related BTB domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107622.2 → NP_001101092.1  rho-related BTB domain-containing protein 1

      See identical proteins and their annotated locations for NP_001101092.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6ATD4, A6JKT8, D3ZD37
      Related
      ENSRNOP00000000784.6, ENSRNOT00000000784.7
      Conserved Domains (3) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592 → 691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464 → 589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      19326197..19455182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098734.2 → XP_038954662.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATD4, A6JKT8, D3ZD37
      Conserved Domains (3) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592 → 691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464 → 589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_063279165.1 → XP_063135235.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6JKT8, D3ZD37

    3. XM_039098733.2 → XP_038954661.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATD4, A6JKT8, D3ZD37
      Conserved Domains (3) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592 → 691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464 → 589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    4. XM_039098737.2 → XP_038954665.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATD4, A6JKT8, D3ZD37
      Conserved Domains (3) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592 → 691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464 → 589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    5. XM_063279164.1 → XP_063135234.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6JKT8, D3ZD37

    6. XM_039098735.2 → XP_038954663.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATD4, A6JKT8, D3ZD37
      Conserved Domains (3) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592 → 691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464 → 589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    7. XM_039098736.2 → XP_038954664.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATD4, A6JKT8, D3ZD37
      Conserved Domains (3) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592 → 691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464 → 589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    8. XM_039098732.2 → XP_038954660.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATD4, A6JKT8, D3ZD37
      Conserved Domains (3) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592 → 691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464 → 589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    9. XM_039098739.2 → XP_038954667.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATD4, A6JKT8, D3ZD37
      Conserved Domains (3) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592 → 691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464 → 589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    10. XM_039098741.2 → XP_038954669.1  rho-related BTB domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ATD4
      Conserved Domains (3) summary
      cd18530
      Location:503 → 602
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:375 → 500
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:10 → 118
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    11. XM_039098743.2 → XP_038954671.1  rho-related BTB domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ATD4
      Conserved Domains (3) summary
      cd18530
      Location:472 → 571
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:344 → 469
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    12. XM_039098740.2 → XP_038954668.1  rho-related BTB domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JWZ1, A0A8I6ATD4
      Related
      ENSRNOP00000070070.2
      Conserved Domains (3) summary
      cd18530
      Location:534 → 633
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:406 → 531
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:41 → 149
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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