Pold1 DNA polymerase delta 1, catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pold1provided by RGD
Official Full Name: DNA polymerase delta 1, catalytic subunitprovided by RGD
Primary source: RGD:621839
See related: Ensembl:ENSRNOG00000019681 AllianceGenome:RGD:621839
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-directed DNA polymerase activity. Involved in DNA biosynthetic process and DNA-dependent DNA replication. Part of delta DNA polymerase complex. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 65.8), Spleen (RPKM 55.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104161984..104178074, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95025462..95041559, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100538066..100554105, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH144354 (e-PCR)
- UniSTS:233599

GDB:583955 (e-PCR)
- UniSTS:157888

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5'-DNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication proofreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication proofreading	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication proofreading	ISO Inferred from Sequence Orthology more info
involved_in DNA synthesis involved in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA synthesis involved in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair, gap-filling	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair, gap-filling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair, gap-filling	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair, gap-filling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in error-free translesion synthesis	IEA Inferred from Electronic Annotation more info
involved_in error-free translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in error-free translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleotide-excision repair, DNA gap filling	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair, DNA gap filling	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair, DNA gap filling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of delta DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of delta DNA polymerase complex	IC Inferred by Curator more info	PubMed
part_of delta DNA polymerase complex	IDA Inferred from Direct Assay more info	PubMed
part_of delta DNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of delta DNA polymerase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleotide-excision repair complex	IEA Inferred from Electronic Annotation more info
part_of nucleotide-excision repair complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA polymerase delta catalytic subunit

Names: 3'-5' exodeoxyribonuclease; DAN polymerase delta 1, catalytic subunit; DNA polymerase delta, catalytic subunit; DNA-directed DNA polymerase delta 1; polymerase (DNA directed), delta 1, catalytic subunit; polymerase (DNA) delta 1, catalytic subunit

NP_067694.1

EC 2.7.7.7

XP_006229204.1

EC 2.7.7.7

XP_063128353.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021662.2 → NP_067694.1 DNA polymerase delta catalytic subunit

See identical proteins and their annotated locations for NP_067694.1

Status: PROVISIONAL

Source sequence(s)

AJ222691

UniProtKB/Swiss-Prot

O54747

UniProtKB/TrEMBL

A6JAQ5

Related

ENSRNOP00000026797.2, ENSRNOT00000026797.5

Conserved Domains (4) summary

cd05777
Location:300 → 529

DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase

cd05533
Location:575 → 970

POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...

PTZ00166
Location:80 → 1096

PTZ00166; DNA polymerase delta catalytic subunit; Provisional

pfam14260
Location:1008 → 1078

zf-C4pol; C4-type zinc-finger of DNA polymerase delta

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104161984..104178074 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229142.5 → XP_006229204.1 DNA polymerase delta catalytic subunit isoform X1

See identical proteins and their annotated locations for XP_006229204.1

UniProtKB/TrEMBL

A6JAQ5, A6JAQ6, G3V8M1

Conserved Domains (1) summary

PTZ00166
Location:80 → 1096

PTZ00166; DNA polymerase delta catalytic subunit; Provisional
XM_063272283.1 → XP_063128353.1 DNA polymerase delta catalytic subunit isoform X1

UniProtKB/TrEMBL

A6JAQ5, A6JAQ6, G3V8M1