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    CIART circadian associated repressor of transcription [ Homo sapiens (human) ]

    Gene ID: 148523, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CIARTprovided by HGNC
    Official Full Name
    circadian associated repressor of transcriptionprovided by HGNC
    Primary source
    HGNC:HGNC:25200
    See related
    Ensembl:ENSG00000159208 MIM:615782; AllianceGenome:HGNC:25200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GM129; CHRONO; C1orf51
    Summary
    Predicted to enable E-box binding activity. Predicted to be involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of transcription, DNA-templated. Predicted to be located in PML body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart (RPKM 6.9), thyroid (RPKM 5.6) and 24 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    1q21.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150282554..150287093)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149407478..149412040)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150254964..150259505)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:150241516-150242127 Neighboring gene uncharacterized LOC124904414 Neighboring gene aph-1 homolog A, gamma-secretase subunit Neighboring gene chromosome 1 open reading frame 54 Neighboring gene Sharpr-MPRA regulatory region 3157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1679 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:150254031-150255230 Neighboring gene uncharacterized LOC105371434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150269465-150270023 Neighboring gene mitochondrial ribosomal protein S21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Tang X, et al. Nat Cell Biol, 2023 Mar. PMID 36918693, Free PMC Article
    2. CHRONO integrates behavioral stress and epigenetic control of metabolism. Hatanaka F, et al. Ann Med, 2017 Jun. PMID 28010116
    3. Machine learning helps identify CHRONO as a circadian clock component. Anafi RC, et al. PLoS Biol, 2014 Apr. PMID 24737000, Free PMC Article
    4. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. Annayev Y, et al. J Biol Chem, 2014 Feb 21. PMID 24385426, Free PMC Article
    5. A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. Goriki A, et al. PLoS Biol, 2014 Apr. PMID 24736997, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25889

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables E-box binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in locomotor rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    circadian-associated transcriptional repressor
    Names
    chIP-derived repressor of network oscillator
    computationally highlighted repressor of the network oscillator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300838.2 → NP_001287767.1  circadian-associated transcriptional repressor isoform a

      See identical proteins and their annotated locations for NP_001287767.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BC027999, CK904668
      Consensus CDS
      CCDS949.1
      UniProtKB/Swiss-Prot
      B2RD43, D3DV01, Q8N365, Q8N795, Q96MG6
      UniProtKB/TrEMBL
      Q8WVX4
      Related
      ENSP00000358091.1, ENST00000369095.5
      Conserved Domains (1) summary
      pfam15673
      Location:92 → 368
      Ciart; Circadian-associated transcriptional repressor

    2. NM_001300839.2 → NP_001287768.1  circadian-associated transcriptional repressor isoform b

      See identical proteins and their annotated locations for NP_001287768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
      Source sequence(s)
      BC017397, CK904668, EB388133
      Consensus CDS
      CCDS72906.1
      UniProtKB/TrEMBL
      Q5TB12, Q8WVX4
      Related
      ENSP00000358090.1, ENST00000369094.5
      Conserved Domains (1) summary
      pfam15673
      Location:4 → 280
      Ciart; Circadian-associated transcriptional repressor

    3. NM_001300840.2 → NP_001287769.1  circadian-associated transcriptional repressor isoform b

      See identical proteins and their annotated locations for NP_001287769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
      Source sequence(s)
      AK056960, CK904668, CN359562, EB388133
      Consensus CDS
      CCDS72906.1
      UniProtKB/TrEMBL
      Q5TB12, Q8WVX4
      Conserved Domains (1) summary
      pfam15673
      Location:4 → 280
      Ciart; Circadian-associated transcriptional repressor

    4. NM_001300841.2 → NP_001287770.1  circadian-associated transcriptional repressor isoform b

      See identical proteins and their annotated locations for NP_001287770.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
      Source sequence(s)
      AC242988, AK056960, BE784098, CK904668, EB388133
      Consensus CDS
      CCDS72906.1
      UniProtKB/TrEMBL
      Q5TB12, Q8WVX4
      Related
      ENSP00000398291.1, ENST00000417398.5
      Conserved Domains (1) summary
      pfam15673
      Location:4 → 280
      Ciart; Circadian-associated transcriptional repressor

    5. NM_144697.4 → NP_653298.1  circadian-associated transcriptional repressor isoform a

      See identical proteins and their annotated locations for NP_653298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC242988, BC047238, CK904668, EB388133
      Consensus CDS
      CCDS949.1
      UniProtKB/Swiss-Prot
      B2RD43, D3DV01, Q8N365, Q8N795, Q96MG6
      UniProtKB/TrEMBL
      Q8WVX4
      Related
      ENSP00000290363.5, ENST00000290363.6
      Conserved Domains (1) summary
      pfam15673
      Location:92 → 368
      Ciart; Circadian-associated transcriptional repressor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      150282554..150287093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446893.1 → XP_047302849.1  circadian-associated transcriptional repressor isoform X1

      UniProtKB/Swiss-Prot
      B2RD43, D3DV01, Q8N365, Q8N795, Q96MG6

    2. XM_024453375.2 → XP_024309143.1  circadian-associated transcriptional repressor isoform X2

      UniProtKB/TrEMBL
      Q5TB12, Q8WVX4
      Conserved Domains (1) summary
      pfam15673
      Location:4 → 280
      Ciart; Circadian-associated transcriptional repressor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      149407478..149412040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334575.1 → XP_054190550.1  circadian-associated transcriptional repressor isoform X1

      UniProtKB/Swiss-Prot
      B2RD43, D3DV01, Q8N365, Q8N795, Q96MG6

    2. XM_054334576.1 → XP_054190551.1  circadian-associated transcriptional repressor isoform X2

      UniProtKB/TrEMBL
      Q5TB12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N365.1 GenPept UniProtKB/Swiss-Prot:Q8N365

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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