hsp70.3 heat shock cognate 70-kd protein, tandem duplicate 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsp70.3provided by ZNC
Official Full Name: heat shock cognate 70-kd protein, tandem duplicate 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-110713-1
See related: Ensembl:ENSDARG00000021924 AllianceGenome:ZFIN:ZDB-GENE-110713-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hsp70; hspa1a; hsp70-4
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Acts upstream of or within camera-type eye morphogenesis. Predicted to be active in cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1B (heat shock protein family A (Hsp70) member 1B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (26123736..26127091)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (25992865..25996220)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Perturbation of the HSP70-HSP90 heat-shock protein axis stimulates degradation of endothelial VEGFR2.
Title: A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.
HSP70, the earliest induced gene in the zebrafish retina after optic nerve injury, is a crucial factor for retinal ganglion cell survival and optic nerve regeneration.
Title: HSP70, the earliest-induced gene in the zebrafish retina during optic nerve regeneration: its role in cell survival.
HSP70 mRNA and protein were increased 2.2 fold at 0.5-24 hours after optic nerve injury then returned to control level.
Title: HSP70 gene expression in the zebrafish retina after optic nerve injury: a comparative study under heat shock stresses.
Hsp70 levels above the median were associated with a higher rate of progression to the accelerated/blast phase and a tendency toward shorter survival
Title: Extracellular heat shock protein 70: a potential prognostic marker for chronic myeloid leukemia.
in rheumatoid arthritis Significantly higher Hsp70 (heat shock protein 70) expression was found on synovial cells than on skin fibroblasts; high co-expression of CD91 and Hsp70 on RA synovial cells
Title: Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints.
These results demonstrate that induction of Hsp70 in response to heat stress is dependent on ERK activation in Pac2 cells.
Title: Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells.
data suggest that HSF1 is involved in regulating constitutive lens specific expression of hsp70 in the embryonic zebrafish.
Title: Heat shock factor 1 is required for constitutive Hsp70 expression and normal lens development in embryonic zebrafish.
gene expression regulation in ZF4 cells by heat and cold
Title: Heat- and cold-inducible regulation of HSP70 expression in zebrafish ZF4 cells.
hsp70 is required for embryonic lens development.
Title: Zebrafish Hsp70 is required for embryonic lens formation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: heat shock cognate 70-kd protein, tandem duplicate 3

Names: etID309743.10; heat shock 70kD protein 1A; stress protein HSP70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131397.3 → NP_571472.2 heat shock cognate 70-kd protein, tandem duplicate 3

See identical proteins and their annotated locations for NP_571472.2

Status: VALIDATED

Source sequence(s)

BC056709

UniProtKB/TrEMBL

A0A8M1PBC6, Q6PH56

Related

ENSDARP00000010413.7, ENSDART00000010477.8

Conserved Domains (2) summary

cd10233
Location:8 → 383

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:5 → 643

PTZ00009; heat shock 70 kDa protein; Provisional