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    Cdk18 cyclin-dependent kinase 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289019, updated on 2-May-2024

    Summary

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    Official Symbol
    Cdk18provided by RGD
    Official Full Name
    cyclin-dependent kinase 18provided by RGD
    Primary source
    RGD:1309523
    See related
    Ensembl:ENSRNOG00000008137 AllianceGenome:RGD:1309523
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pctk3; PCTAIRE3
    Summary
    Predicted to enable ATP binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein serine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDK18 (cyclin dependent kinase 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 53.4), Liver (RPKM 22.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk18 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46107763..46140705, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43555597..43582210, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48893525..48926673, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481494 Neighboring gene ETS transcription factor ELK4 Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene uncharacterized LOC134481495 Neighboring gene BLACAT1 overlapping LEMD1 locus Neighboring gene microRNA 135b Neighboring gene LEM domain containing 1 Neighboring gene kelch domain containing 8A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. Hirose T, et al. Eur J Biochem, 1997 Oct 15. PMID 9370357
    2. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 18
    Names
    PCTAIRE protein kinase 3
    PCTAIRE-motif protein kinase 3
    cell division protein kinase 18
    serine/threonine-protein kinase PCTAIRE-3
    NP_001093976.1
    XP_006249813.1
    XP_063128137.1
    XP_063128138.1
    XP_063128140.1
    XP_063128141.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100506.1 → NP_001093976.1  cyclin-dependent kinase 18

      See identical proteins and their annotated locations for NP_001093976.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082045
      UniProtKB/Swiss-Prot
      O35832
      UniProtKB/TrEMBL
      A0A0H2UHG4, Q641Z0
      Related
      ENSRNOP00000095753.1, ENSRNOT00000114199.1
      Conserved Domains (1) summary
      cl21453
      Location:115 → 402
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      46107763..46140705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272068.1 → XP_063128138.1  cyclin-dependent kinase 18 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A946

    2. XM_063272067.1 → XP_063128137.1  cyclin-dependent kinase 18 isoform X1

    3. XM_063272071.1 → XP_063128141.1  cyclin-dependent kinase 18 isoform X3

      UniProtKB/Swiss-Prot
      O35832
      UniProtKB/TrEMBL
      Q641Z0

    4. XM_006249751.5 → XP_006249813.1  cyclin-dependent kinase 18 isoform X3

      See identical proteins and their annotated locations for XP_006249813.1

      UniProtKB/Swiss-Prot
      O35832
      UniProtKB/TrEMBL
      A0A0H2UHG4, Q641Z0
      Conserved Domains (1) summary
      cl21453
      Location:115 → 402
      PKc_like; Protein Kinases, catalytic domain

    5. XM_063272070.1 → XP_063128140.1  cyclin-dependent kinase 18 isoform X3

      UniProtKB/Swiss-Prot
      O35832
      UniProtKB/TrEMBL
      Q641Z0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35832.1 GenPept UniProtKB/Swiss-Prot:O35832

    Gene LinkOut

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