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    Gtf2a1 general transcription factor 2A subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83830, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Gtf2a1provided by RGD
    Official Full Name
    general transcription factor 2A subunit 1provided by RGD
    Primary source
    RGD:69246
    See related
    Ensembl:ENSRNOG00000004300 AllianceGenome:RGD:69246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tf2a; TfIIa
    Summary
    Predicted to enable several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; RNA polymerase II general transcription initiation factor activity; and TBP-class protein binding activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIIA complex; transcription factor TFIID complex; and transcription preinitiation complex. Orthologous to human GTF2A1 (general transcription factor IIA subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 145.9), Kidney (RPKM 140.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2a1 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (116219614..116252220, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (110488891..110521502, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (115321110..115352659, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 128 Neighboring gene thyroid stimulating hormone receptor Neighboring gene small nucleolar RNA SNORA79 Neighboring gene uncharacterized LOC134479244 Neighboring gene stonin 2 Neighboring gene acid phosphatase 1, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. Ma D, et al. Genes Dev, 1993 Nov. PMID 8224850
    2. Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. Ozer J, et al. J Biol Chem, 1996 May 10. PMID 8626665
    3. Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription. Sun X, et al. Genes Dev, 1994 Oct 1. PMID 7958900
    4. Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. DeJong J, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7724559, Free PMC Article
    5. Structural insights into transcription initiation by RNA polymerase II. Grünberg S, et al. Trends Biochem Sci, 2013 Dec. PMID 24120742, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor IIA subunit 1
    Names
    TFIIA large subunit
    general transcription factor 2a, 1
    general transcription factor IIA subunit 1
    general transcription factor IIa, 1 (37kD and 19kD subunits)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022208.2 → NP_071544.1  transcription initiation factor IIA subunit 1

      See identical proteins and their annotated locations for NP_071544.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      O08949
      UniProtKB/TrEMBL
      A0A8I6A0U6, A6JEC8
      Related
      ENSRNOP00000005873.1, ENSRNOT00000005873.4
      Conserved Domains (1) summary
      pfam03153
      Location:13 → 377
      TFIIA; Transcription factor IIA, alpha/beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      116219614..116252220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240410.4 → XP_006240472.1  transcription initiation factor IIA subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6APY1
      Conserved Domains (1) summary
      pfam03153
      Location:1 → 338
      TFIIA; Transcription factor IIA, alpha/beta subunit

    2. XM_039112999.2 → XP_038968927.1  transcription initiation factor IIA subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6APY1
      Conserved Domains (1) summary
      pfam03153
      Location:1 → 338
      TFIIA; Transcription factor IIA, alpha/beta subunit

    3. XM_039113000.2 → XP_038968928.1  transcription initiation factor IIA subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6APY1
      Related
      ENSRNOP00000086237.1
      Conserved Domains (1) summary
      pfam03153
      Location:1 → 338
      TFIIA; Transcription factor IIA, alpha/beta subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08949.1 GenPept UniProtKB/Swiss-Prot:O08949

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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