mt-Co1 cytochrome c oxidase I, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: mt-Co1provided by RGD
Official Full Name: cytochrome c oxidase I, mitochondrialprovided by RGD
Primary source: RGD:621871
See related: AllianceGenome:RGD:621871
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: COI; COX1
Summary: Predicted to enable heme binding activity and metal ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Involved in several processes, including cerebellum development; response to copper ion; and response to electrical stimulus. Located in mitochondrion. Used to study hepatocellular carcinoma. Biomarker of Parkinsonism. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2023_06	latest, but not current	mRatBN7.2 (GCF_015227675.2)	MT (non-nuclear)	NC_001665.2 (5323..6867)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	MT (non-nuclear)	NC_001665.2 (5323..6867)

Chromosome MT - NC_001665.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytochrome c Oxidase Activity as a Metabolic Regulator in Pancreatic Beta-Cells.
Title: Cytochrome c Oxidase Activity as a Metabolic Regulator in Pancreatic Beta-Cells.
Interacting network of the gap junction protein connexin43, which includes Ryr2 and Cox1, is modulated by ischemia and reperfusion in the heart.
Title: Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart.
This study thus demonstrates that VEGF recovers PE-suppressed COX activity by restoring Cu availability.
Title: Vascular endothelial growth factor recovers suppressed cytochrome c oxidase activity by restoring copper availability in hypertrophic cardiomyocytes.
Ca(2+)- binding at the Cation Binding Site is proposed to inhibit proton-transfer through the exit part of the proton conducting pathway H in the mammalian oxidases.
Title: Direct regulation of cytochrome c oxidase by calcium ions.
The expression of COX I and COX IV proteins during hypoxic exposure is coordinately regulated by post-transcriptional mechanisms.
Title: [Effects of hypoxic exposure on coordinative expression of cytochrome oxidase subunits I and IV in rat cerebral cortex].
Chronic intermittent hypoxia exposure could decrease mitochondrial COX protein expression and activity in the genioglossus, while estrogen administration might help recover activity.
Title: [Effects of estrogen on activity and subunits expression of cytochrome C oxidase in mitochondria from genioglossus of rats subjected to chronic intermittent hypoxia].
Ischemia-reperfusion induces inhibition of mitochondrial protein synthesis and cytochrome c oxidase activity in rat hippocampus.
Title: Ischemia-reperfusion induces inhibition of mitochondrial protein synthesis and cytochrome c oxidase activity in rat hippocampus.
In remodelled arteries following photochemical endothelial injury, the vasoconstrictive prostanoids PGH2 and PGF2alpha contribute to changes in endothelium-dependent vascular response via COX-1- and 2-dependent pathways.
Title: Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries.
The expression of COX-2 mRNA in the colon was upregulated on day 3 during DSS treatment, with significant increase of prostaglandin E(2) PGE(2) production.
Title: Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats.
In liver, T3 thyroid hormone induced a coordinated increase in the expression of the nuclear (COX Vb) and mitochondrial (COX I) genomes at the protein level.
Title: Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Co1; Cox1

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info
enables cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info
contributes_to cytochrome-c oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in electron transport coupled proton transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex III	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 1

Names: cytochrome c oxidase subunit I

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001665.2 Reference assembly

Range

5323..6867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_665631.1 cytochrome c oxidase subunit I (mitochondrion) [Rattus norvegicus]

See identical proteins and their annotated locations for YP_665631.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P05503

UniProtKB/TrEMBL

Q06QA9, Q06QK0, Q8HIC9

Related

ENSRNOP00000039048.3

Conserved Domains (2) summary

MTH00153
Location:4 → 507

COX1; cytochrome c oxidase subunit I; Provisional

pfam00115
Location:14 → 460

COX1; Cytochrome C and Quinol oxidase polypeptide I