Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndufv2provided by RGD
Official Full Name: NADH:ubiquinone oxidoreductase core subunit V2provided by RGD
Primary source: RGD:621733
See related: Ensembl:ENSRNOG00000042503 AllianceGenome:RGD:621733
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in cardiac muscle tissue development; mitochondrial electron transport, NADH to ubiquinone; and nervous system development. Predicted to be located in cytosol; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Orthologous to human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 3952.0), Muscle (RPKM 3168.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q37

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (113137305..113157571, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (105690454..105710669, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (113875718..113900169, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NECA prevents mitochondrial oxidative stress by decreasing mitochondrial superoxide generation through inhibition of complex I via the mitochondrial Src tyrosine kinase. Phosphorylation of Tyr(118) residue in NDUFV2 subunit may account for the inhibitory effect of NECA on complex I.
Title: Adenosine A(2) receptor activation ameliorates mitochondrial oxidative stress upon reperfusion through the posttranslational modification of NDUFV2 subunit of complex I in the heart.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex I	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex I	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Names: 24-kDa subunit of mitochondrial NADH dehydrogenase; NADH dehydrogenase (ubiquinone) flavoprotein 2; NADH-ubiquinone oxidoreductase 24 kDa subunit

NP_112326.1

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031064.2 → NP_112326.1 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor

See identical proteins and their annotated locations for NP_112326.1

Status: PROVISIONAL

Source sequence(s)

BC058495

UniProtKB/Swiss-Prot

P19234, Q6PDU9

UniProtKB/TrEMBL

A6JRE1, A6JRE2

Related

ENSRNOP00000016965.4, ENSRNOT00000016965.6

Conserved Domains (2) summary

COG1905
Location:50 → 211

NuoE; NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]

pfam01257
Location:62 → 208

2Fe-2S_thioredx; Thioredoxin-like [2Fe-2S] ferredoxin