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    Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171518, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cyp2c22provided by RGD
    Official Full Name
    cytochrome P450, family 2, subfamily c, polypeptide 22provided by RGD
    Primary source
    RGD:620368
    See related
    Ensembl:ENSRNOG00000021924 AllianceGenome:RGD:620368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp2c70; P-450Md; CYPIIC70
    Summary
    Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 4672.9) See more
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    Genomic context

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    See Cyp2c22 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (248941143..248980767, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (238991698..239031323, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (259257658..259297270, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485236 Neighboring gene U6 spliceosomal RNA Neighboring gene PDZ and LIM domain 1 Neighboring gene sorbin and SH3 domain containing 1 Neighboring gene uncharacterized LOC120097534

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver. Qian L, et al. J Lipid Res, 2010 Jul. PMID 20147703, Free PMC Article
    2. cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats. Nagata K, et al. Nucleic Acids Res, 1990 Aug 25. PMID 2395662, Free PMC Article
    3. A different cytochrome P450 form is induced in primary cultures of rat hepatocytes. Emi Y, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 2263625, Free PMC Article
    4. Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes. Lee CM, et al. J Pharmacol Exp Ther, 2014 Jan. PMID 24144795, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYP2C22 protein is rapidly downregulated in primary rat hepatocytes by interleukin(IL)-1beta or nitric oxide-donating compounds.
      Title: Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes.
    2. Data demonstrate that CYP2C22 is a high-abundance, retinoid-inducible, hepatic P450 with the potential to metabolize at-RA, providing additional insight into the role of the CYP2C gene family in retinoid homeostasis.
      Title: Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 2C70
    Names
    cytochrome P-450Md
    cytochrome P450 2c22
    cytochrome P450 P49
    cytochrome P450, family 2, subfamily c, polypeptide 70
    NP_612521.2
    XP_038946459.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138512.2 → NP_612521.2  cytochrome P450 2C70 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P19225
      UniProtKB/TrEMBL
      A6JH55, B5AMZ7
      Conserved Domains (1) summary
      cd20665
      Location:61 → 484
      CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      248941143..248980767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090531.1 → XP_038946459.1  cytochrome P450 2C70 isoform X1

      UniProtKB/Swiss-Prot
      P19225
      UniProtKB/TrEMBL
      A6JH55, B5AMZ7
      Related
      ENSRNOP00000051607.2, ENSRNOT00000054724.3
      Conserved Domains (1) summary
      cd20665
      Location:61 → 484
      CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19225.1 GenPept UniProtKB/Swiss-Prot:P19225

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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