Hbb hemoglobin subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hbbprovided by RGD
Official Full Name: hemoglobin subunit betaprovided by RGD
Primary source: RGD:2783
See related: Ensembl:ENSRNOG00000047098 AllianceGenome:RGD:2783
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables hemoglobin alpha binding activity and hemoglobin beta binding activity. Contributes to oxygen binding activity. Involved in glutathione metabolic process and oxygen transport. Part of hemoglobin complex. Biomarker of anemia. Human ortholog(s) of this gene implicated in acute chest syndrome; hemolytic anemia (multiple); malaria; polycythemia (multiple); and sickle cell anemia. Orthologous to several human genes including HBB (hemoglobin subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 320827.9), Lung (RPKM 72635.9) and 1 other tissue See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (167662310..167663721, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (158250421..158251832, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (168971269..168972680, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders.
Title: LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders.
GH regulates the expression of cerebrocortical beta-globin, GABAB receptor 1, and the Lissencephaly-1 protein (LIS-1) in adult hypophysectomized rats.
Title: Peripheral administration of bovine GH regulates the expression of cerebrocortical beta-globin, GABAB receptor 1, and the Lissencephaly-1 protein (LIS-1) in adult hypophysectomized rats.
Results report that hemoglobin chains alpha2 nad beta are expressed in mammalian brain neurons and are regulated by a mitochondrial toxin.
Title: Neurons express hemoglobin alpha- and beta-chains in rat and human brains.
the activities of the minimal promoters of rat beta (IIbeta, IIIbeta, and 0beta)-globin genes are proportional to the gene expression levels in vivo; erythroid-specific repressor regions immediately upstream are regulated by the same transcription factor
Title: Molecular cloning and characterization of three adult rat beta-globin gene promoters.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

PMC106412P1 (e-PCR)
- UniSTS:270119

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:516684

PMC350564P1 (e-PCR)
- UniSTS:273240

PMC18810P1 (e-PCR)
- UniSTS:271733

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:531320

RH94431 (e-PCR)
- UniSTS:119679

PMC140912P1 (e-PCR)
- UniSTS:270982

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:525965

PMC153210P1 (e-PCR)
- UniSTS:271251

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:516509

D1Bda30 (e-PCR)
- UniSTS:239777

RH94473 (e-PCR)
- UniSTS:119721

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:499134

BI280228 (e-PCR)
- UniSTS:249026

PMC21968P1 (e-PCR)
- UniSTS:272086

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:143326

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to haptoglobin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to haptoglobin binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables hemoglobin alpha binding	IBA Inferred from Biological aspect of Ancestor more info
enables hemoglobin alpha binding	IDA Inferred from Direct Assay more info	PubMed
enables hemoglobin beta binding	IDA Inferred from Direct Assay more info	PubMed
enables hemoglobin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables organic acid binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	ISO Inferred from Sequence Orthology more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	ISO Inferred from Sequence Orthology more info
contributes_to peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to peroxidase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbon dioxide transport	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide transport	ISO Inferred from Sequence Orthology more info
involved_in oxygen transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxygen transport	ISO Inferred from Sequence Orthology more info
involved_in oxygen transport	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme	ISO Inferred from Sequence Orthology more info
involved_in renal absorption	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of haptoglobin-hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of haptoglobin-hemoglobin complex	ISO Inferred from Sequence Orthology more info
part_of hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IDA Inferred from Direct Assay more info	PubMed
part_of hemoglobin complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: hemoglobin subunit beta-1

Names: III beta-1 globin; III beta-2 globin; beta-1-globin; hemoglobin beta chain complex; hemoglobin beta chain, major-form; hemoglobin beta-1 chain; hemoglobin, beta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.