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    Rnmt RNA (guanine-7-) methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291534, updated on 2-May-2024

    Summary

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    Official Symbol
    Rnmtprovided by RGD
    Official Full Name
    RNA (guanine-7-) methyltransferaseprovided by RGD
    Primary source
    RGD:1309242
    See related
    Ensembl:ENSRNOG00000016698 AllianceGenome:RGD:1309242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. Predicted to be active in nucleus. Orthologous to human RNMT (RNA guanine-7 methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 105.0), Brain (RPKM 88.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnmt in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (64156067..64179601)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61886230..61909775)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (64084746..64108246)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 1 Neighboring gene family with sequence similarity 210, member A Neighboring gene melanocortin 5 receptor Neighboring gene melanocortin 2 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. Bujnicki JM, et al. BMC Bioinformatics, 2001. PMID 11472630, Free PMC Article
    2. Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM. Varshney D, et al. Nucleic Acids Res, 2016 Dec 1. PMID 27422871, Free PMC Article
    3. Cap-binding complex (CBC). Gonatopoulos-Pournatzis T, et al. Biochem J, 2014 Jan 15. PMID 24354960, Free PMC Article
    4. RAM/Fam103a1 is required for mRNA cap methylation. Gonatopoulos-Pournatzis T, et al. Mol Cell, 2011 Nov 18. PMID 22099306, Free PMC Article
    5. Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. Tsukamoto T, et al. Biochem Biophys Res Commun, 1998 Oct 9. PMID 9790902

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94587

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 7-methylguanosine mRNA capping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in RNA 5'-cap (guanine-N7)-methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cap methyltransferase RNMT:RAMAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cap methyltransferase RNMT:RAMAC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mRNA capping enzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mRNA capping enzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mRNA cap guanine-N7 methyltransferase
    Names
    RG7MT1
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase
    NP_001008300.1
    XP_006254956.1
    XP_006254957.1
    XP_006254958.1
    XP_038952589.1
    XP_063133260.1
    XP_063133261.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008299.2 → NP_001008300.1  mRNA cap guanine-N7 methyltransferase

      See identical proteins and their annotated locations for NP_001008300.1

      Status: VALIDATED

      Source sequence(s)
      BC085858, CN543861
      UniProtKB/Swiss-Prot
      Q5U2U7
      UniProtKB/TrEMBL
      A0A8I6AG46, A6IXX3
      Related
      ENSRNOP00000022410.4, ENSRNOT00000022410.5
      Conserved Domains (1) summary
      pfam03291
      Location:124 → 460
      Pox_MCEL; mRNA capping enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      64156067..64179601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254896.5 → XP_006254958.1  mRNA cap guanine-N7 methyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006254958.1

      UniProtKB/TrEMBL
      A0A8I5Y8Y9, A6IXX4
      Related
      ENSRNOP00000076517.1
      Conserved Domains (2) summary
      COG0500
      Location:156 → 344
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17173
      Location:124 → 405
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_006254894.3 → XP_006254956.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006254956.1

      UniProtKB/Swiss-Prot
      Q5U2U7
      UniProtKB/TrEMBL
      A0A8I6AG46, A6IXX3
      Conserved Domains (1) summary
      pfam03291
      Location:124 → 460
      Pox_MCEL; mRNA capping enzyme

    3. XM_063277191.1 → XP_063133261.1  mRNA cap guanine-N7 methyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y8Y9, A6IXX4

    4. XM_039096661.2 → XP_038952589.1  mRNA cap guanine-N7 methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U7
      UniProtKB/TrEMBL
      A0A8I6AG46, A6IXX3
      Conserved Domains (1) summary
      pfam03291
      Location:124 → 460
      Pox_MCEL; mRNA capping enzyme

    5. XM_006254895.5 → XP_006254957.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006254957.1

      UniProtKB/Swiss-Prot
      Q5U2U7
      UniProtKB/TrEMBL
      A0A8I6AG46, A6IXX3
      Conserved Domains (1) summary
      pfam03291
      Location:124 → 460
      Pox_MCEL; mRNA capping enzyme

    6. XM_063277190.1 → XP_063133260.1  mRNA cap guanine-N7 methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q5U2U7
      UniProtKB/TrEMBL
      A6IXX3

    RNA

    1. XR_005496003.2 RNA Sequence

    2. XR_010059551.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2U7.1 GenPept UniProtKB/Swiss-Prot:Q5U2U7

    Gene LinkOut

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