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    Papola poly (A) polymerase alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314417, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Papolaprovided by RGD
    Official Full Name
    poly (A) polymerase alphaprovided by RGD
    Primary source
    RGD:1308673
    See related
    Ensembl:ENSRNOG00000004827 AllianceGenome:RGD:1308673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation and regulation of mRNA 3'-end processing. Predicted to act upstream of or within RNA polyadenylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human PAPOLA (poly(A) polymerase alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 312.5), Spleen (RPKM 302.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Papola in Genome Data Viewer
    Location:
    6q32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (130446236..130499371)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (124682015..124734706)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (129609068..129662002)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479256 Neighboring gene GSK3B interacting protein Neighboring gene adenylate kinase 7 Neighboring gene transfer RNA proline (anticodon AGG) 18 Neighboring gene uncharacterized LOC120103616 Neighboring gene uncharacterized LOC134479472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ERK is a novel regulatory kinase for poly(A) polymerase. Lee SH, et al. Nucleic Acids Res, 2008 Feb. PMID 18084034, Free PMC Article
    2. The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. Murthy KG, et al. Genes Dev, 1995 Nov 1. PMID 7590244
    3. Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. Kiefer H, et al. J Biol Chem, 2009 Apr 17. PMID 19224921, Free PMC Article
    4. Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Gruber AR, et al. Wiley Interdiscip Rev RNA, 2014 Mar-Apr. PMID 24243805, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytosolic mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) polymerase alpha
    NP_001101526.1
    XP_006240583.1
    XP_038968319.1
    XP_038968320.1
    XP_038968321.1
    XP_038968322.1
    XP_038968323.1
    XP_038968324.1
    XP_038968325.1
    XP_038968326.1
    XP_063118075.1
    XP_063118076.1
    XP_063118077.1
    XP_063118078.1
    XP_063118079.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108056.2 → NP_001101526.1  poly(A) polymerase alpha

      See identical proteins and their annotated locations for NP_001101526.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K0C9, A6KBD5
      Related
      ENSRNOP00000071393.2, ENSRNOT00000083732.2
      Conserved Domains (4) summary
      PTZ00418
      Location:9 → 567
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:366 → 495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21 → 363
      PAP_central; Poly(A) polymerase central domain
      pfam11035
      Location:599 → 668
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      130446236..130499371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112397.2 → XP_038968325.1  poly(A) polymerase alpha isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0C9
      Conserved Domains (3) summary
      PRK12799
      Location:516 → 662
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:381 → 510
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:36 → 378
      PAP_central; Poly(A) polymerase central domain

    2. XM_039112394.2 → XP_038968322.1  poly(A) polymerase alpha isoform X6

      UniProtKB/TrEMBL
      A0A0G2K0C9
      Conserved Domains (3) summary
      PRK12799
      Location:516 → 655
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:381 → 510
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:36 → 378
      PAP_central; Poly(A) polymerase central domain

    3. XM_039112391.2 → XP_038968319.1  poly(A) polymerase alpha isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0C9
      Conserved Domains (3) summary
      PRK12799
      Location:516 → 661
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:381 → 510
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:36 → 378
      PAP_central; Poly(A) polymerase central domain

    4. XM_039112393.2 → XP_038968321.1  poly(A) polymerase alpha isoform X5

      UniProtKB/TrEMBL
      A0A8I6A6U9
      Conserved Domains (3) summary
      PRK12799
      Location:516 → 661
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:381 → 510
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:36 → 378
      PAP_central; Poly(A) polymerase central domain

    5. XM_006240521.5 → XP_006240583.1  poly(A) polymerase alpha isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0C9, A0A8I6G751
      Related
      ENSRNOP00000082223.1
      Conserved Domains (4) summary
      PTZ00418
      Location:9 → 567
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:366 → 495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21 → 363
      PAP_central; Poly(A) polymerase central domain
      pfam11035
      Location:599 → 668
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb

    6. XM_063262006.1 → XP_063118076.1  poly(A) polymerase alpha isoform X8

      UniProtKB/TrEMBL
      A0A0G2K0C9

    7. XM_063262008.1 → XP_063118078.1  poly(A) polymerase alpha isoform X12

      UniProtKB/TrEMBL
      A0A8I6G740

    8. XM_063262005.1 → XP_063118075.1  poly(A) polymerase alpha isoform X7

      UniProtKB/TrEMBL
      A0A0G2K0C9

    9. XM_063262007.1 → XP_063118077.1  poly(A) polymerase alpha isoform X9

      UniProtKB/TrEMBL
      A0A0G2K0C9

    10. XM_063262009.1 → XP_063118079.1  poly(A) polymerase alpha isoform X13

      UniProtKB/TrEMBL
      A0A8I6G740

    11. XM_039112396.2 → XP_038968324.1  poly(A) polymerase alpha isoform X11

      UniProtKB/TrEMBL
      A0A8I6A6U9
      Conserved Domains (3) summary
      PRK12799
      Location:516 → 661
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:381 → 510
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:36 → 378
      PAP_central; Poly(A) polymerase central domain

    12. XM_039112392.2 → XP_038968320.1  poly(A) polymerase alpha isoform X4

      UniProtKB/TrEMBL
      A0A8I6A6U9, D3ZK96
      Related
      ENSRNOP00000060627.2
      Conserved Domains (3) summary
      PRK12799
      Location:516 → 662
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:381 → 510
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:36 → 378
      PAP_central; Poly(A) polymerase central domain

    13. XM_039112395.2 → XP_038968323.1  poly(A) polymerase alpha isoform X10

      UniProtKB/TrEMBL
      A0A8I6A6U9
      Conserved Domains (3) summary
      PRK12799
      Location:516 → 662
      motB; flagellar motor protein MotB; Reviewed
      pfam04926
      Location:381 → 510
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:36 → 378
      PAP_central; Poly(A) polymerase central domain

    14. XM_039112398.2 → XP_038968326.1  poly(A) polymerase alpha isoform X14

      Conserved Domains (3) summary
      PRK12799
      Location:251 → 397
      motB; flagellar motor protein MotB; Reviewed
      PTZ00418
      Location:1 → 317
      PTZ00418; Poly(A) polymerase; Provisional
      cl11966
      Location:1 → 113
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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