Pigf phosphatidylinositol glycan anchor biosynthesis, class F [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pigfprovided by RGD
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Fprovided by RGD
Primary source: RGD:1584658
See related: Ensembl:ENSRNOG00000015325 AllianceGenome:RGD:1584658
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human PIGF (phosphatidylinositol glycan anchor biosynthesis class F). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 164.6), Thymus (RPKM 159.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (13343134..13371237)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (7589584..7617719)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (10565841..10593972, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thus, a tilt in the angiogenic balance toward anti-angiogenic sFlt-1 is associated with decreased vascular relaxation and increased vasoconstriction and BP. Restoring the angiogenic/antiangiogenic balance using PlGF enhances endothelial NO-cGMP vascular relaxation and decreases vasoconstriction and BP in HTN-Preg rats and could offer a new approach in the management of PE.
Title: Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mannose-ethanolamine phosphotransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol-glycan biosynthesis class F protein

NP_001385898.2

EC 2.7.8.1

NP_001385899.2

EC 2.7.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398969.2 → NP_001385898.2 phosphatidylinositol-glycan biosynthesis class F protein

Status: VALIDATED

Source sequence(s)

BP495818, JAXUCZ010000006

UniProtKB/TrEMBL

A6H9F1

Related

ENSRNOP00000079359.1, ENSRNOT00000101571.1
NM_001398970.2 → NP_001385899.2 phosphatidylinositol-glycan biosynthesis class F protein

Status: VALIDATED

Source sequence(s)

BP495818, JAXUCZ010000006

UniProtKB/TrEMBL

A6H9F1