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    Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361351, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Hdhd2provided by RGD
    Official Full Name
    haloacid dehalogenase-like hydrolase domain containing 2provided by RGD
    Primary source
    RGD:1308579
    See related
    Ensembl:ENSRNOG00000043171 AllianceGenome:RGD:1308579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ier3ip1; LRRG00122; RGD1308579
    Summary
    Predicted to enable enzyme binding activity and phosphatase activity. Predicted to be involved in several processes, including organ growth; positive regulation of secretion by cell; and regulation of fibroblast apoptotic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to several human genes including HDHD2 (haloacid dehalogenase like hydrolase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 75.4), Adrenal (RPKM 67.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (72763313..72801679)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (70488315..70526471)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (73226630..73278062)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SKI family transcriptional corepressor 2 Neighboring gene uncharacterized LOC120098312 Neighboring gene uncharacterized LOC134483057 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene protein inhibitor of activated STAT, 2 Neighboring gene uncharacterized LOC102552068 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two candidate genes for two quantitative trait loci epistatically attenuate hypertension in a novel pathway. Chauvet C, et al. J Hypertens, 2015 Sep. PMID 26103128
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hdhd2 appears to act from upstream in a pathway by regulating Tcof1/treacle possibly at the level of post-translation.
      Title: Two candidate genes for two quantitative trait loci epistatically attenuate hypertension in a novel pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    haloacid dehalogenase-like hydrolase domain-containing protein 2
    Names
    immediate early response 3-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412497.1 → NP_001399426.1  haloacid dehalogenase-like hydrolase domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q6AYR6
      UniProtKB/TrEMBL
      A6KMT8
      Related
      ENSRNOP00000075095.1, ENSRNOT00000080660.2

    2. NM_001412498.1 → NP_001399427.1  haloacid dehalogenase-like hydrolase domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q6AYR6
      UniProtKB/TrEMBL
      A6KMT8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      72763313..72801679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014151.2: Suppressed sequence

      Description
      NM_001014151.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYR6.1 GenPept UniProtKB/Swiss-Prot:Q6AYR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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