Pou3f4 POU class 3 homeobox 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pou3f4provided by RGD
Official Full Name: POU class 3 homeobox 4provided by RGD
Primary source: RGD:61947
See related: Ensembl:ENSRNOG00000002784 AllianceGenome:RGD:61947
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RHS2
Summary: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in X-linked deafness 2. Orthologous to human POU3F4 (POU class 3 homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: Xq31

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (79974808..79976085)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (75858646..75859923)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (82143789..82145066)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicated that Brn4 promoted the neuronal differentiation of neural stem cells via inhibition of CtBP2 and is a potential tool for generating neurons in cell replacement therapy of neurodegenerative diseases and brain injury
Title: Brn4 promotes the differentiation of radial glial cells into neurons by inhibiting CtBP2.
The co-transduction of Nurr1 and Brn4 genes induces cell differentiation of neural stem cells
Title: The co-transduction of Nurr1 and Brn4 genes induces the differentiation of neural stem cells into dopaminergic neurons.
Brn-4 expression is required both for neuronal differentiation of NSCs and maturation of newborn neurons, and that there may be some regulatory factors in deafferented hippocampus that can regulate Brn-4 expression in neuronal progenitors.
Title: The role of Brn-4 in the regulation of neural stem cell differentiation into neurons.
study showed after fimbria-fornix lesion, Brn-4 in deafferented hippocampus was upregulated & might play a role in inducing local progenitors to differentiate into neurons, which may compensate for loss of cholinergic afferent fibers or other dysfunctions
Title: Brn-4 is upregulated in the deafferented hippocampus and promotes neuronal differentiation of neural progenitors in vitro.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pou3f4 (e-PCR), detects polymorphism
- UniSTS:507168

AU049792 (e-PCR)
- UniSTS:146238

Pou3f4 (e-PCR), detects polymorphism
- UniSTS:144244

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within forebrain neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: POU domain, class 3, transcription factor 4

Names: OTF-9; RHS2 class III POU protein; brain-4; brain-specific homeobox/POU domain protein 4; brn-4; oct-9; octamer-binding protein 9; octamer-binding transcription factor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017252.2 → NP_058948.1 POU domain, class 3, transcription factor 4

See identical proteins and their annotated locations for NP_058948.1

Status: VALIDATED

Source sequence(s)

M84645, Z11834

UniProtKB/Swiss-Prot

P62516

UniProtKB/TrEMBL

A6IV85

Related

ENSRNOP00000003724.4, ENSRNOT00000003724.7

Conserved Domains (2) summary

smart00352
Location:186 → 260

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:281 → 335

Homeobox; Homeobox domain