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    Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171521, updated on 11-Apr-2024

    Summary

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    Symbol
    Cyp2c13provided by RGD
    Full Name
    cytochrome P450, family 2, subfamily c, polypeptide 13provided by RGD
    Primary source
    RGD:620363
    See related
    Ensembl:ENSRNOG00000049464 AllianceGenome:RGD:620363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp2c38
    Summary
    Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Orthologous to human CYP2C8 (cytochrome P450 family 2 subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 2978.9) See more
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    Genomic context

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    Location:
    1q53
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (248706787..248787239, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (238786764..238867195, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (258796624..258877023, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene igE-binding protein-like Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 12 Neighboring gene uncharacterized LOC134485236 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a cDNA for rat P-450g, a highly polymorphic, male-specific cytochrome in the P-450IIC subfamily. McClellan-Green PD, et al. Biochemistry, 1989 Jul 11. PMID 2775738
    2. Characterization of a cDNA for the unexpressed form of cytochrome P-450g from the (-g) rat and differentiation of its mRNA from that of the (+g) phenotype using specific oligoprobes. Yeowell HN, et al. Biochemistry, 1990 Jan 23. PMID 2337591
    3. Structural and regulatory analysis of the male-specific rat liver cytochrome P-450 g: repression by continuous growth hormone administration. Zaphiropoulos PG, et al. Mol Endocrinol, 1990 Jan. PMID 2325668
    4. Gene structure and expression of the rat cytochrome P450IIC13, a polymorphic, male-specific cytochrome in the P450IIC subfamily. Eguchi H, et al. Biochemistry, 1991 Nov 12. PMID 1834171
    5. Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. Matsumoto T, et al. J Biochem, 1986 Nov. PMID 2434473

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114253

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2C13, male-specific
    Names
    CYP2C13 (+)
    CYPIIC13
    P-450g
    P450-G
    UT-5
    cytochrome P-450g
    cytochrome P450 2C13, male-specific-like
    cytochrome P450 g (+)
    cytochrome P450, 2c38
    cytochrome P450-G
    cytochrome P450-UT-5
    NP_612523.1
    XP_038946817.1
    XP_038946856.1
    XP_038946894.1
    XP_063133702.1
    XP_063133714.1
    XP_063133724.1
    XP_063133732.1
    XP_063133747.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138514.1 → NP_612523.1  cytochrome P450 2C13, male-specific

      See identical proteins and their annotated locations for NP_612523.1

      Status: PROVISIONAL

      Source sequence(s)
      M32277
      UniProtKB/Swiss-Prot
      P20814, P22693, Q64587
      UniProtKB/TrEMBL
      M0RD38, Q5I0P5
      Related
      ENSRNOP00000067531.1, ENSRNOT00000071633.4
      Conserved Domains (1) summary
      pfam00067
      Location:30 → 487
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      248706787..248787239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277632.1 → XP_063133702.1  cytochrome P450 2C13, male-specific isoform X1

    2. XM_063277644.1 → XP_063133714.1  cytochrome P450 2C13, male-specific isoform X2

    3. XM_039090889.2 → XP_038946817.1  cytochrome P450 2C13, male-specific isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZKW5
      Conserved Domains (1) summary
      cd20665
      Location:61 → 431
      CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s

    4. XM_063277654.1 → XP_063133724.1  cytochrome P450 2C13, male-specific isoform X3

    5. XM_063277662.1 → XP_063133732.1  cytochrome P450 2C13, male-specific isoform X3

    6. XM_063277677.1 → XP_063133747.1  cytochrome P450 2C13, male-specific isoform X5

    7. XM_039090966.2 → XP_038946894.1  cytochrome P450 2C13, male-specific isoform X7

      Conserved Domains (1) summary
      cl41757
      Location:61 → 273
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    8. XM_039090928.2 → XP_038946856.1  cytochrome P450 2C13, male-specific isoform X6

      Conserved Domains (1) summary
      cl41757
      Location:61 → 281
      cytochrome_P450; cytochrome P450 (CYP) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20814.1 GenPept UniProtKB/Swiss-Prot:P20814

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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