Serpina6 serpin family A member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpina6provided by RGD
Official Full Name: serpin family A member 6provided by RGD
Primary source: RGD:1595901
See related: Ensembl:ENSRNOG00000009438 AllianceGenome:RGD:1595901
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cbg
Summary: Predicted to enable serine-type endopeptidase inhibitor activity and steroid binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within glucocorticoid metabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in corticosteroid-binding globulin deficiency. Orthologous to human SERPINA6 (serpin family A member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3523.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (128544828..128555064, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (122780040..122790274, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (127523948..127534178, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Corticosteroid-Binding Globulin (SERPINA6) Consolidates Sexual Dimorphism of Adult Rat Liver.
Title: Corticosteroid-Binding Globulin (SERPINA6) Consolidates Sexual Dimorphism of Adult Rat Liver.
Corticosteroid-binding Globulin (SERPINA6) Establishes Postpubertal Sex Differences in Rat Adrenal Development.
Title: Corticosteroid-binding Globulin (SERPINA6) Establishes Postpubertal Sex Differences in Rat Adrenal Development.
N-glycans at other sites also appear to protect CBG from neutrophil elastase or chymotrypsin.
Title: Functional implications of corticosteroid-binding globulin N-glycosylation.
levels and integrity of plasma CBG are biomarkers of the onset and severity of inflammation
Title: Corticosteroid-binding globulin is a biomarker of inflammation onset and severity in female rats.
It is most likely that CBG in the brain may be involved in the response to changing systemic glucocorticoid levels.
Title: Differences in colocalization of corticosteroid-binding globulin and glucocorticoid receptor immunoreactivity in the rat brain.
corticosteroid binding globulin
Title: Expression of corticosteroid binding globulin in the rat olfactory system.
Food restriction induced higher corticosterone plasma concentration at both ages, but only in pups did CBG binding increase after short- and long-term treatments
Title: Fasting differentially regulates plasma corticosterone-binding globulin, glucocorticoid receptor, and cell cycle in the gastric mucosa of pups and adult rats.
analysis of the structural basis for steroid transport and proteinase-triggered release of CBG
Title: Corticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered release.
multiple locations of corticosteroid binding globulin throughout the central nervous system suggest multiple functional properties, including neuroendocrine and neurohumoral functions
Title: Expression of corticosteroid binding globulin in the rat central nervous system.

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General gene information

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Markers

BF388405 (e-PCR)
- UniSTS:244941

RH127840 (e-PCR)
- UniSTS:211150

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within glucocorticoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: corticosteroid-binding globulin

Names: Corticosteroid binding globulin; serine (or cysteine) peptidase inhibitor, clade A, member 6; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; serpin A6; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; serpin peptidase inhibitor, clade A, member 6; transcortin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009663.1 → NP_001009663.1 corticosteroid-binding globulin precursor

See identical proteins and their annotated locations for NP_001009663.1

Status: PROVISIONAL

Source sequence(s)

BC088300

UniProtKB/Swiss-Prot

P31211, Q5M822

Related

ENSRNOP00000012500.4, ENSRNOT00000012500.8

Conserved Domains (1) summary

cd02056
Location:37 → 392

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...