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    Zfyve28 zinc finger FYVE-type containing 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305454, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfyve28provided by RGD
    Official Full Name
    zinc finger FYVE-type containing 28provided by RGD
    Primary source
    RGD:1310151
    See related
    Ensembl:ENSRNOG00000014874 AllianceGenome:RGD:1310151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 69.7), Thymus (RPKM 8.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfyve28 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (80692997..80778606)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (76468424..76554039)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (81725513..81811142)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 99 Neighboring gene ring finger protein 4 Neighboring gene uncharacterized LOC103693090 Neighboring gene uncharacterized LOC120096643 Neighboring gene Max dimerization protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Mosesson Y, et al. Dev Cell, 2009 May. PMID 19460345, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lateral signaling target protein 2 homolog
    Names
    zinc finger, FYVE domain containing 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107227.1 → NP_001100697.1  lateral signaling target protein 2 homolog

      See identical proteins and their annotated locations for NP_001100697.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A6IK36, D3ZTZ1
      Related
      ENSRNOP00000020154.5, ENSRNOT00000020154.6
      Conserved Domains (1) summary
      cd15731
      Location:828 → 892
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      80692997..80778606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251256.5 → XP_006251318.1  lateral signaling target protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMR3
      Related
      ENSRNOP00000079387.1
      Conserved Domains (1) summary
      cd15731
      Location:840 → 904
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    2. XM_006251258.5 → XP_006251320.1  lateral signaling target protein 2 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y5G8
      Related
      ENSRNOP00000077191.1

    3. XM_006251259.5 → XP_006251321.1  lateral signaling target protein 2 homolog isoform X3

      Conserved Domains (1) summary
      pfam05109
      Location:510 → 705
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RNA

    1. XR_005492958.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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