Pgrmc2 progesterone receptor membrane component 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pgrmc2provided by RGD
Official Full Name: progesterone receptor membrane component 2provided by RGD
Primary source: RGD:1308804
See related: Ensembl:ENSRNOG00000014051 AllianceGenome:RGD:1308804
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heme binding activity and heme transmembrane transporter activity. Predicted to be involved in adipose tissue development and heme transport. Predicted to be located in endoplasmic reticulum and nuclear envelope. Predicted to be active in endomembrane system and membrane. Orthologous to human PGRMC2 (progesterone receptor membrane component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 218.2), Heart (RPKM 179.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (125996190..126012090, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (124068257..124084155, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (127986106..128002005, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGRMC1 and PGRMC2 are involved in regulating entry into the G1 stage of the cell cycle.
Title: Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells.
Pgrmc1 and Pgrmc2 may play roles in neuroendocrine functions of the female rat.
Title: Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heme transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: membrane-associated progesterone receptor component 2

Names: progesterone membrane binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008374.1 → NP_001008375.1 membrane-associated progesterone receptor component 2

See identical proteins and their annotated locations for NP_001008375.1

Status: PROVISIONAL

Source sequence(s)

BC083571

UniProtKB/Swiss-Prot

Q5XIU9

UniProtKB/TrEMBL

A6II47

Related

ENSRNOP00000018796.4, ENSRNOT00000018796.5

Conserved Domains (1) summary

pfam00173
Location:98 → 161

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain