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    Stac3 SH3 and cysteine rich domain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362895, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Stac3provided by RGD
    Official Full Name
    SH3 and cysteine rich domain 3provided by RGD
    Primary source
    RGD:1308964
    See related
    Ensembl:ENSRNOG00000008050 AllianceGenome:RGD:1308964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including neuromuscular synaptic transmission; positive regulation of protein localization to plasma membrane; and positive regulation of voltage-gated calcium channel activity. Predicted to act upstream of or within skeletal muscle fiber development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of voltage-gated calcium channel complex. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC3 (SH3 and cysteine rich domain 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 601.4) and Liver (RPKM 80.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stac3 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65227151..65235884)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63343078..63350590)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70807427..70815271)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene R3H domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene peptidyl-prolyl cis-trans isomerase D-like Neighboring gene NDUFA4, mitochondrial complex associated like 2 Neighboring gene serine hydroxymethyltransferase 2 Neighboring gene neurexophilin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. STAC3 stably interacts through its C1 domain with Ca(V)1.1 in skeletal muscle triads. Campiglio M, et al. Sci Rep, 2017 Jan 23. PMID 28112192, Free PMC Article
    2. Stac3 is a novel regulator of skeletal muscle development in mice. Reinholt BM, et al. PLoS One, 2013. PMID 23626854, Free PMC Article
    3. Testicular STAC3 regulates Leydig cell steroidogenesis through potentiating mitochondrial membrane potential and StAR processing. Bi X, et al. Cell Tissue Res, 2021 Apr. PMID 33409656, Free PMC Article
    4. Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation. Polster A, et al. Proc Natl Acad Sci U S A, 2016 Sep 27. PMID 27621462, Free PMC Article
    5. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Testicular STAC3 regulates Leydig cell steroidogenesis through potentiating mitochondrial membrane potential and StAR processing.
      Title: Testicular STAC3 regulates Leydig cell steroidogenesis through potentiating mitochondrial membrane potential and StAR processing.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuromuscular synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 and cysteine-rich domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130558.1 → NP_001124030.1  SH3 and cysteine-rich domain-containing protein 3

      See identical proteins and their annotated locations for NP_001124030.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HQV7, D3ZQN6
      Related
      ENSRNOP00000010639.4, ENSRNOT00000010639.5
      Conserved Domains (4) summary
      cd11834
      Location:307 → 357
      SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
      cd11986
      Location:248 → 300
      SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
      pfam00130
      Location:89 → 134
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam16664
      Location:146 → 218
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      65227151..65235884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263831.1 → XP_063119901.1  SH3 and cysteine-rich domain-containing protein 3 isoform X2

    2. XM_063263829.1 → XP_063119899.1  SH3 and cysteine-rich domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A6HQV7, D3ZQN6

    3. XM_063263830.1 → XP_063119900.1  SH3 and cysteine-rich domain-containing protein 3 isoform X2

    4. XM_017594944.3 → XP_017450433.1  SH3 and cysteine-rich domain-containing protein 3 isoform X2

    5. XM_008765415.4 → XP_008763637.1  SH3 and cysteine-rich domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_008763637.1

      UniProtKB/TrEMBL
      A6HQV7, D3ZQN6
      Conserved Domains (4) summary
      cd11834
      Location:307 → 357
      SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
      cd11986
      Location:248 → 300
      SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
      pfam00130
      Location:89 → 134
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam16664
      Location:146 → 218
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

    6. XM_006241486.5 → XP_006241548.1  SH3 and cysteine-rich domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006241548.1

      UniProtKB/TrEMBL
      A6HQV7, D3ZQN6
      Conserved Domains (4) summary
      cd11834
      Location:307 → 357
      SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
      cd11986
      Location:248 → 300
      SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
      pfam00130
      Location:89 → 134
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam16664
      Location:146 → 218
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

    7. XM_006241488.5 → XP_006241550.1  SH3 and cysteine-rich domain-containing protein 3 isoform X3

      Conserved Domains (4) summary
      cd11834
      Location:268 → 318
      SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
      cd11986
      Location:209 → 261
      SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
      pfam00130
      Location:50 → 95
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam16664
      Location:107 → 179
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    Nucleotide Protein Strain
    Heading Accession and Version

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