Ogfr opioid growth factor receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ogfrprovided by RGD
Official Full Name: opioid growth factor receptorprovided by RGD
Primary source: RGD:69324
See related: Ensembl:ENSRNOG00000009355 AllianceGenome:RGD:69324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable opioid growth factor receptor activity. Predicted to be involved in regulation of growth. Predicted to be located in membrane; nucleus; and perinuclear region of cytoplasm. Orthologous to human OGFR (opioid growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 202.8), Spleen (RPKM 173.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (188080743..188087028)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (167703173..167709459)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (176093662..176099949)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulation of the OGF-OGFr pathway correlates with elevated serum OGF and ocular surface complications in the diabetic rat.
Title: Dysregulation of the OGF-OGFr pathway correlates with elevated serum OGF and ocular surface complications in the diabetic rat.
Blockade of the OGF-OGFr pathway in diabetic bone.
Title: Blockade of the OGF-OGFr pathway in diabetic bone.
Opioid growth factor receptor colocalizes with opioid growth factor in the paranuclear cytoplasm and cell nuclei in basal, as well as suprabasal, cells of adult rat corneal epithelium.
Title: Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea.
OGFr was detected in whole brain at embryonic day 20 and birth, and was at least twofold greater than neonatal levels during the first week of life.
Title: Gene expression of OGFr in the developing and adult rat brain and cerebellum.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables opioid growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: opioid growth factor receptor

Names: zeta-type opioid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053340.2 → NP_445792.2 opioid growth factor receptor

See identical proteins and their annotated locations for NP_445792.2

Status: VALIDATED

Source sequence(s)

BC101898, BP501519, EV778659

UniProtKB/Swiss-Prot

Q9QXY4

UniProtKB/TrEMBL

Q3MID9

Related

ENSRNOP00000073386.2, ENSRNOT00000086541.2

Conserved Domains (2) summary

pfam04664
Location:76 → 283

OGFr_N; Opioid growth factor receptor (OGFr) conserved region

pfam15231
Location:405 → 549

VCX_VCY; Variable charge X/Y family