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    Igfbp7 insulin-like growth factor binding protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 29817, updated on 2-May-2024

    Summary

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    Official Symbol
    Igfbp7provided by MGI
    Official Full Name
    insulin-like growth factor binding protein 7provided by MGI
    Primary source
    MGI:MGI:1352480
    See related
    Ensembl:ENSMUSG00000036256 AllianceGenome:MGI:1352480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AGM; Fstl2; Mac25
    Summary
    Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within inner ear development. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 2884.8), ovary adult (RPKM 2858.2) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.3; 5 41.71 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77497092..77555892, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (77349240..77408045, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:77704983-77705284 Neighboring gene microRNA 5098 Neighboring gene RE1-silencing transcription factor Neighboring gene STARR-seq mESC enhancer starr_13474 Neighboring gene nitric oxide associated 1 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide B Neighboring gene predicted gene, 34648 Neighboring gene STARR-seq mESC enhancer starr_13478 Neighboring gene predicted gene, 34728 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:77889021-77889208 Neighboring gene STARR-positive B cell enhancer ABC_E6341 Neighboring gene RIKEN cDNA 1700017L05 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation. Yu JT, et al. Kidney Int, 2022 Oct. PMID 35752325
    2. Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis. Zhang H, et al. Sci Transl Med, 2021 Oct 6. PMID 34613814
    3. IGFBP7 aggravates sepsis-induced acute lung injury by activating the ERK1/2 pathway. Xu Q, et al. Folia Histochem Cytobiol, 2020. PMID 33326113
    4. IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Akiel M, et al. Cancer Res, 2017 Aug 1. PMID 28619711, Free PMC Article
    5. Mesenchymal Stromal Cells Mitigate Experimental Colitis via Insulin-like Growth Factor Binding Protein 7-mediated Immunosuppression. Liao Y, et al. Mol Ther, 2016 Oct. PMID 27397633, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural insight into CD93 recognition by IGFBP7.
      Title: Structural insight into CD93 recognition by IGFBP7.
    2. METTL3-mediated m[6]A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
      Title: METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
    3. Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation.
      Title: Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation.
    4. IGFBP7 aggravates sepsis-induced acute lung injury by activating the ERK1/2 pathway.
      Title: IGFBP7 aggravates sepsis-induced acute lung injury by activating the ERK1/2 pathway.
    5. Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease.
      Title: Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease.
    6. The mechanism may be that eleutheroside B can activate the insulin-like growth factor (IGF) pathway and its downstream pathway by downregulating the expression of IGFBP-7, thus promoting cell proliferation. Therefore, our results suggest that eleutheroside B is a potential drug for Acute kidney injury (AKI) treatment.
      Title: Eleutheroside B Protects against Acute Kidney Injury by Activating IGF Pathway.
    7. IGFBP7 inhibited receptor activation of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced osteoclastogenesis.
      Title: IGFBP7 acts as a negative regulator of RANKL-induced osteoclastogenesis and oestrogen deficiency-induced bone loss.
    8. IGFBP7 has a role in regulating sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling
      Title: IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling.
    9. IGFBPrP1 promoted autophagy and contributed to hepatic stellate cell activation via mutual regulation between H19 and the PI3K/AKT/mTOR pathway.
      Title: IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway.
    10. Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses hepatocellular carcinoma
      Title: IGFBP7 Deletion Promotes Hepatocellular Carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner ear development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 7
    Names
    IBP-7
    IGF-binding protein 7
    IGFBP-7
    angiomodulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159518.2 → NP_001152990.2  insulin-like growth factor-binding protein 7 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122396, AC141469
      Consensus CDS
      CCDS51530.1
      UniProtKB/TrEMBL
      E9Q5D9, F8WH23
      Related
      ENSMUSP00000128318.3, ENSMUST00000163898.6
      Conserved Domains (3) summary
      smart00121
      Location:31 → 89
      IB; Insulin growth factor-binding protein homologues
      smart00280
      Location:110 → 155
      KAZAL; Kazal type serine protease inhibitors
      smart00409
      Location:204 → 295
      IG; Immunoglobulin

    2. NM_008048.4 → NP_032074.4  insulin-like growth factor-binding protein 7 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC122396, AC141469
      Consensus CDS
      CCDS51529.1
      UniProtKB/Swiss-Prot
      O88812, Q61581, Q9EQW0
      UniProtKB/TrEMBL
      F8WH23
      Related
      ENSMUSP00000045057.8, ENSMUST00000046746.10
      Conserved Domains (4) summary
      smart00121
      Location:31 → 89
      IB; Insulin growth factor-binding protein homologues
      smart00280
      Location:110 → 155
      KAZAL; Kazal type serine protease inhibitors
      cd00096
      Location:174 → 183
      Ig; Ig strand B [structural motif]
      cl11960
      Location:159 → 264
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      77497092..77555892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61581.3 GenPept UniProtKB/Swiss-Prot:Q61581

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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