EXG1 glucan 1,3-beta-glucosidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: EXG1
Gene description: glucan 1,3-beta-glucosidase
Primary source: FungiDB:YLR300W
Locus tag: YLR300W
See related: SGD:S000004291; AllianceGenome:SGD:S000004291; VEuPathDB:YLR300W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BGL1; SCW6
Summary: Predicted to enable glucan exo-1,3-beta-glucosidase activity. Involved in cellular glucan metabolic process. Located in extracellular region and fungal-type cell wall. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EXG1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (728955..730301)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec14 function was required for the route followed by Bgl2, whereas trafficking of other secreted proteins, including Hsp150, Cts1, Scw4, Scw10, Exg1, Cis3, and Ygp1, still occurred, indicating Sec14 regulates specific trans-Golgi export pathways.
Title: Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glucan exo-1,3-beta-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucan exo-1,3-beta-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables glucan exo-1,3-beta-glucosidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glucan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: glucan 1,3-beta-glucosidase

NP_013403.1

EC 3.2.1.58

Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

728955..730301

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182188.1 → NP_013403.1 TPA: glucan 1,3-beta-glucosidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013403.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYU4, P23776, Q9UR92

UniProtKB/TrEMBL

A0A6A5PVK2, A7A1I1, B3RHH9, B5VNK2, C7GVT9, C8ZDR3, G2WJC2, N1NYJ3

Conserved Domains (1) summary

COG2730
Location:36 → 448

BglC; Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism]