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    MAS1 mitochondrial processing peptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850860, updated on 19-Jun-2024

    Summary

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    Gene symbol
    MAS1
    Gene description
    mitochondrial processing peptidase
    Primary source
    FungiDB:YLR163C
    Locus tag
    YLR163C
    See related
    SGD:S000004153; AllianceGenome:SGD:S000004153; VEuPathDB:YLR163C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MIF1
    Summary
    Contributes to metalloendopeptidase activity. Involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Part of mitochondrial processing peptidase complex. Used to study multiple mitochondrial dysfunctions syndrome 6. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple mitochondrial dysfunctions syndrome 6. Orthologous to several human genes including PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MAS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (491866..493254, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rrt15p Neighboring gene protein SHH4 Neighboring gene pseudouridine synthase PUS5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. Witte C, et al. EMBO J, 1988 May. PMID 3044780, Free PMC Article
    2. More than just a ticket canceller: the mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites. Friedl J, et al. Mol Biol Cell, 2020 Nov 15. PMID 32997570, Free PMC Article
    3. An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates. Poveda-Huertes D, et al. Mol Cell, 2020 Jan 2. PMID 31630969, Free PMC Article
    4. Quantitative Profiling for Substrates of the Mitochondrial Presequence Processing Protease Reveals a Set of Nonsubstrate Proteins Increased upon Proteotoxic Stress. Burkhart JM, et al. J Proteome Res, 2015 Nov 6. PMID 26446170
    5. A computational study of the glycine-rich loop of mitochondrial processing peptidase. Kučera T, et al. PLoS One, 2013. PMID 24058582, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing involved in protein targeting to mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial processing peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial processing peptidase
    NP_013264.1
    • Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      491866..493254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182050.1 → NP_013264.1  TPA: mitochondrial processing peptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013264.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYG9, P10507
      UniProtKB/TrEMBL
      A0A6A5PV67, A7A156, B5VN86, C7GIV6, C8ZDD5, G2WIZ8, N1NZC6
      Conserved Domains (1) summary
      COG0612
      Location:12 → 453
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10507.1

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