Myh10 myosin heavy chain 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh10provided by RGD
Official Full Name: myosin heavy chain 10provided by RGD
Primary source: RGD:71000
See related: Ensembl:ENSRNOG00000002886 AllianceGenome:RGD:71000
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MCH-B; SMemb; NMMHC-B
Summary: Enables identical protein binding activity. Involved in several processes, including actin filament bundle organization; modification of postsynaptic actin cytoskeleton; and regulation of modification of postsynaptic actin cytoskeleton. Located in lamellipodium. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human MYH10 (myosin heavy chain 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 265.9), Brain (RPKM 225.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (53891955..54024032)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53393901..53525174)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55274910..55406738)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
Title: Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
Study suggests that NMIIB remains constitutively active in support of methamphetamine associations, continuing to drive actin polymerization, such that memories associated with methamphetamine can be selectively targeted without the need for retrieval days to weeks after learning
Title: Nonmuscle myosin IIB as a therapeutic target for the prevention of relapse to methamphetamine use.
NM II maintains proper morphology of neuronal growth cones and the distal axon by regulating actin dynamics through the guanine nucleotide exchange factor-Rho GTPase signaling pathway.
Title: Non-muscle myosin II regulates neuronal actin dynamics by interacting with guanine nucleotide exchange factors.
FHL1 exists as part of a complex, which binds gamma-actin and non-muscle myosin IIB
Title: Identification of an FHL1 protein complex containing gamma-actin and non-muscle myosin IIB by analysis of protein-protein interactions.
NM II manages several major processes involved in the beta cell response to glucose, including gamma-actin protrusion and remodelling, FA assembly and turnover, and the secretory granule approach to the basal membrane
Title: Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion.
IIb MHC transcriptional regulation during muscle maturation to the adult state is consistent with the previously defined model of antisense-mediated coordination of genomically adjacent MHC genes, as is evident in the transcriptionally divergent euthyroid and hypothyroid states.
Title: Regulation of an antisense RNA with the transition of neonatal to IIb myosin heavy chain during postnatal development and hypothyroidism in rat skeletal muscle.
These data support the idea that Myosin II motor-force generation is a general mechanism that supports memory consolidation in the mammalian CNS.
Title: Myosin II motor activity in the lateral amygdala is required for fear memory consolidation.
visual stimulation may play a role in the signals that regulate both nmMyH IIB and EO-MyHC developmental transitions
Title: Postnatal changes in the developing rat extraocular muscles.
myosin IIb motor activity is downstream of LTP induction and is necessary for the emergence of actin structures that stabilize an early phase of LTP, and myosin IIb activity contributes to an actin-dependent process that underlies memory consolidation
Title: Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation.
These results provide important insights related to how proximal IIb MHC promoter elements regulate the increased expression of the IIb MHC gene in response to inactivity of a predominantly slow postural muscle.
Title: Transcriptional regulation of the myosin heavy chain IIb gene in inactive rat soleus.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_24284-24285:1030045561:1 (e-PCR)
- UniSTS:268872

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	IEA Inferred from Electronic Annotation more info
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 5'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IEA Inferred from Electronic Annotation more info
contributes_to microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle distribution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin filament-based movement	ISO Inferred from Sequence Orthology more info
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac myofibril assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac septum development	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cerebellar Purkinje cell layer development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fourth ventricle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral ventricle development	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myofibril assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate-dependent cell migration, cell extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within third ventricle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular cardiac muscle cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actomyosin	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	ISO Inferred from Sequence Orthology more info
located_in myosin II filament	IEA Inferred from Electronic Annotation more info
located_in myosin II filament	ISO Inferred from Sequence Orthology more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-10

Names: MCH-B(B2); NMMHC II-b; NMMHC-IIB; cellular myosin heavy chain, type B; myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscle type B; myosin, heavy chain 10, non-muscle; myosin, heavy polypeptide 10, non-muscle; non-muscle myosin heavy chain B; non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain IIB; nonmuscle myosin heavy chain-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031520.2 → NP_113708.2 myosin-10

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9JLT0

UniProtKB/TrEMBL

A6HFL0

Related

ENSRNOP00000077816.1, ENSRNOT00000105761.1

Conserved Domains (3) summary

cd14920
Location:99 → 771

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

53891955..54024032

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597544.3 → XP_017453033.1 myosin-10 isoform X1

UniProtKB/Swiss-Prot

Q9JLT0

UniProtKB/TrEMBL

A0A8I6GLM0

Conserved Domains (10) summary

cd14920
Location:99 → 802

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:87 → 802

Myosin_head; Myosin head (motor domain)

pfam01576
Location:879 → 1959

Myosin_tail_1; Myosin tail

pfam02736
Location:34 → 72

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1631 → 1641

GBP_C; coiled coil [structural motif]

cl19511
Location:1142 → 1253

DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

cl19818
Location:1676 → 1727

DUF106; Integral membrane protein DUF106

cl20817
Location:1535 → 1641

GBP_C; Guanylate-binding protein, C-terminal domain

cl21509
Location:1224 → 1371

ApoLp-III_like; Apolipophorin-III and similar insect proteins

cl24005
Location:1800 → 1898

DUF2570; Protein of unknown function (DUF2570)
XM_063269927.1 → XP_063125997.1 myosin-10 isoform X3

UniProtKB/TrEMBL

G3V9Y1
XM_063269926.1 → XP_063125996.1 myosin-10 isoform X2

UniProtKB/TrEMBL

A0A8I6A5G4
XM_063269928.1 → XP_063125998.1 myosin-10 isoform X4

UniProtKB/TrEMBL

A6HFL0
XM_063269925.1 → XP_063125995.1 myosin-10 isoform X1

UniProtKB/TrEMBL

A0A8I6GLM0
XM_063269929.1 → XP_063125999.1 myosin-10 isoform X4

UniProtKB/TrEMBL

A6HFL0